ID   PXR1_CANGA              Reviewed;         288 AA.
AC   Q6FTR8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Protein PXR1;
DE   AltName: Full=PinX1-related protein 1;
GN   Name=PXR1; OrderedLocusNames=CAGL0G00264g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC       regulates negatively telomerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
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DR   EMBL; CR380953; CAG59303.1; -; Genomic_DNA.
DR   RefSeq; XP_446376.1; XM_446376.1.
DR   AlphaFoldDB; Q6FTR8; -.
DR   STRING; 5478.XP_446376.1; -.
DR   EnsemblFungi; CAG59303; CAG59303; CAGL0G00264g.
DR   GeneID; 2888416; -.
DR   KEGG; cgr:CAGL0G00264g; -.
DR   CGD; CAL0129340; CAGL0G00264g.
DR   VEuPathDB; FungiDB:CAGL0G00264g; -.
DR   eggNOG; KOG2809; Eukaryota.
DR   HOGENOM; CLU_052839_0_0_1; -.
DR   InParanoid; Q6FTR8; -.
DR   Proteomes; UP000002428; Chromosome G.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:EnsemblFungi.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:EnsemblFungi.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0010521; F:telomerase inhibitor activity; IEA:EnsemblFungi.
DR   GO; GO:0000494; P:box C/D RNA 3'-end processing; IEA:EnsemblFungi.
DR   GO; GO:0032211; P:negative regulation of telomere maintenance via telomerase; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR000467; G_patch_dom.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..288
FT                   /note="Protein PXR1"
FT                   /id="PRO_0000324885"
FT   DOMAIN          25..72
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          147..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..233
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   288 AA;  32893 MW;  6D5A00B6329C0B02 CRC64;
     MGLAAVKTRQ KFGLDPRNTA WSNDQSRFGH KHLMRFGWQP GQGLGTQPVQ SMKTHIKVSI
     KDDNLGLGAK LKKNKGDKID EFDNGECAGL DVFQRILGRL NGKETEVNKE LEIQRKDKIL
     NGKWGVHFVK GDTLASTWDP KTKKLLSYSQ MEKDSSSDEE SDDDEDEKKK HKIEKKEAKK
     SKKRKRDSES DSESKKKKKS KKDKKEKKSK KDKKNKKEKE SKKDKKSKHK KDKKQEIRTA
     SIESSTSATS IPESVSTRLS VRSKWIKQKR AAVMDSKALN EIFMVTGN