ID   PXR1_CHAGB              Reviewed;         368 AA.
AC   Q2HFA6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Protein PXR1;
DE   AltName: Full=PinX1-related protein 1;
GN   Name=PXR1; ORFNames=CHGG_01098;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC       regulates negatively telomerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAQ92863.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH408029; EAQ92863.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001220319.1; XM_001220318.1.
DR   AlphaFoldDB; Q2HFA6; -.
DR   STRING; 38033.XP_001220319.1; -.
DR   PRIDE; Q2HFA6; -.
DR   EnsemblFungi; EAQ92863; EAQ92863; CHGG_01098.
DR   GeneID; 4387049; -.
DR   eggNOG; KOG2809; Eukaryota.
DR   HOGENOM; CLU_052839_0_0_1; -.
DR   InParanoid; Q2HFA6; -.
DR   OrthoDB; 1577610at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR000467; G_patch_dom.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..368
FT                   /note="Protein PXR1"
FT                   /id="PRO_0000324886"
FT   DOMAIN          25..79
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..188
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..308
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  40618 MW;  1F0492C562C4685A CRC64;
     MGLAGAKNKR KLGNDPNNTK WSRNTDTFGQ KILRAQGWQP GEYLGAKDAA HAEWHTEANT
     THIRVTLKDD TLGLGAKRNN GDECTGLDAF QHLLGRLNGK SDEALEAEQK VRNDVKLSLY
     IQKKFGMMRF VKGGWLVGDQ VKQTPDEEAE EIPDSTETSE APEPAAVESK KRKADRRSDK
     EDDKLGKKEK KSKKRKAGSE GDVGGEGGQK EKDKKSKRRK TESDECEEPA VTPKTAESLD
     EASGASEAGN TKNEKKDKKR DKKEKKERRD KKEKKEKRRI EKAAAESGAE TGDSISEEKK
     RKKKEATSEP SSAPTPTDSN SSTPTGSGYS TPIPTGSSRY LARSRFIAQK KMAFADSAAL
     NQIFMIKS