ID   PXR1_COCIM              Reviewed;         317 AA.
AC   Q1DQE9; J3K422;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Protein PXR1;
DE   AltName: Full=PinX1-related protein 1;
GN   Name=PXR1; ORFNames=CIMG_07464;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC       regulates negatively telomerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAS28718.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; GG704913; EAS28718.3; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001240301.1; XM_001240300.2.
DR   AlphaFoldDB; Q1DQE9; -.
DR   STRING; 246410.Q1DQE9; -.
DR   EnsemblFungi; EAS28718; EAS28718; CIMG_07464.
DR   GeneID; 4559399; -.
DR   KEGG; cim:CIMG_07464; -.
DR   InParanoid; Q1DQE9; -.
DR   OrthoDB; 1577610at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR000467; G_patch_dom.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..317
FT                   /note="Protein PXR1"
FT                   /id="PRO_0000324887"
FT   DOMAIN          25..79
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          152..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..194
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..250
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   317 AA;  35479 MW;  92E1FE636AC1C52E CRC64;
     MGLAGPKKRT KISHDPNNIA WSRSTTGYGH RIMSAQGWTP GAFLGAPGAA HSSCYTAASA
     SHIRVVLKDD TLGLGARPRN PLAEDEPTGL DAFQDLLGRL NGKSEVELVK EQRRREDIKL
     LSFVERRWKS MAFVPGGYLV KEDPARTLVV AEQANKDDSS DPKSRQETTQ KRPKKEKRKE
     KSRHREEPID SRSISSKPER GTINSANQTS DDESTNIVPS ESKSRKKEKK KKSKKRKMDE
     VNEEESVPDG RIGCKGILPN KQSAQQSTGE RYISGDSMIN AREHRPLGRQ VIRSRYIQQK
     KMALLDAKSL NEIFMTS