ID   PXR1_LODEL              Reviewed;         345 AA.
AC   A5E4P1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Protein PXR1;
DE   AltName: Full=PinX1-related protein 1;
GN   Name=PXR1; ORFNames=LELG_04580;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC       regulates negatively telomerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH981529; EDK46399.1; -; Genomic_DNA.
DR   RefSeq; XP_001524608.1; XM_001524558.1.
DR   AlphaFoldDB; A5E4P1; -.
DR   STRING; 379508.A5E4P1; -.
DR   EnsemblFungi; EDK46399; EDK46399; LELG_04580.
DR   GeneID; 5231354; -.
DR   KEGG; lel:LELG_04580; -.
DR   VEuPathDB; FungiDB:LELG_04580; -.
DR   eggNOG; KOG2809; Eukaryota.
DR   HOGENOM; CLU_052839_0_0_1; -.
DR   InParanoid; A5E4P1; -.
DR   OMA; WDQSSEA; -.
DR   OrthoDB; 1577610at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR005819; H1/H5.
DR   Pfam; PF01585; G-patch; 1.
DR   PRINTS; PR00624; HISTONEH5.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..345
FT                   /note="Protein PXR1"
FT                   /id="PRO_0000324890"
FT   DOMAIN          25..71
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..289
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        290..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  40308 MW;  8AD20372DFEA2B49 CRC64;
     MGLAGTKVKQ RFGLDPRNTN WSNNNNQFGH QYLTKMGWTP GKGIGLVPDS ITTHLKINIK
     TDNAGLGAKL QKRNKDANEL DECSGVDAFQ RILGRLNGKE DAVNKVMDMK RDDMIINGKM
     GIRFVKGEVL SSTWDKEKKA LISYANGKNE DKKDKDEVSL LRKRKVEDEE KREVKKSRKD
     IKEKKEKKEK KEKKEKKEKK EKKEKKEKKE KKEKKEKKEK KEKKEKKEKK EKSDKKEKKE
     KKDKKEKKEK KEKKEKKEKK EKKEKKEKKE KKEKKEKKEK KDKLDKESSN AANVESTKSL
     VSDSSRESTP TPIASRLSVR SKWIKQKRAS VMDAKALNEI FMISN