ID   PXR1_NEUCR              Reviewed;         369 AA.
AC   Q7SHT5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Protein pxr-1;
DE   AltName: Full=PinX1-related protein 1;
GN   Name=pxr-1; ORFNames=NCU02528;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC       regulates negatively telomerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
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DR   EMBL; CM002236; EAA36423.1; -; Genomic_DNA.
DR   RefSeq; XP_965659.1; XM_960566.2.
DR   AlphaFoldDB; Q7SHT5; -.
DR   STRING; 5141.EFNCRP00000002062; -.
DR   EnsemblFungi; EAA36423; EAA36423; NCU02528.
DR   GeneID; 3881857; -.
DR   KEGG; ncr:NCU02528; -.
DR   VEuPathDB; FungiDB:NCU02528; -.
DR   HOGENOM; CLU_052839_0_0_1; -.
DR   InParanoid; Q7SHT5; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0090069; P:regulation of ribosome biogenesis; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR000467; G_patch_dom.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..369
FT                   /note="Protein pxr-1"
FT                   /id="PRO_0000324893"
FT   DOMAIN          25..79
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..287
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..319
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..338
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  41741 MW;  11848041FFA04F42 CRC64;
     MGLAAAKNKR KLGTDPNNTK WSRNETTFGQ KILRAQGWQP GEFLGAKDAA HAVHHTEASS
     SHIKVTLKDD NLGLGAKRNN GDECTGLFDF QHLLGRLNGK SEDVLEAEKQ KRENHIRNHY
     LEQKIGTIRF VRGGWLVGDV VKEKVTEEDG VPQSDTVDQQ VETVPSQDTK DAEPTKRKSK
     KRKADSDEED EKEEKKDKKV KKRKTDTEAE TDSESSRSKK KEKKDKKEKK DQKEKKDKKD
     KRKLKDAKQS EESSSDDLES SATETKKSKK DKKKEKKEKK DKKKDKKEKK RKEKELSDSA
     TESEDSKSKA QKRTKDGAEI ETSTPGGSGT STPTVTSSTR FLARQRFIAQ KKMAFTDSAA
     LNQIFMIKS