PXR1_PICGU
ID PXR1_PICGU Reviewed; 286 AA.
AC A5DRH5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein PXR1;
DE AltName: Full=PinX1-related protein 1;
GN Name=PXR1; ORFNames=PGUG_05876;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC regulates negatively telomerase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
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DR EMBL; CH408162; EDK41778.2; -; Genomic_DNA.
DR RefSeq; XP_001482113.1; XM_001482063.1.
DR AlphaFoldDB; A5DRH5; -.
DR STRING; 4929.XP_001482113.1; -.
DR EnsemblFungi; EDK41778; EDK41778; PGUG_05876.
DR GeneID; 5123849; -.
DR KEGG; pgu:PGUG_05876; -.
DR VEuPathDB; FungiDB:PGUG_05876; -.
DR eggNOG; KOG2809; Eukaryota.
DR HOGENOM; CLU_052839_0_0_1; -.
DR InParanoid; A5DRH5; -.
DR OMA; WDQSSEA; -.
DR OrthoDB; 1577610at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR000467; G_patch_dom.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000305"
FT CHAIN 2..286
FT /note="Protein PXR1"
FT /id="PRO_0000324895"
FT DOMAIN 25..71
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 286 AA; 32788 MW; 6EFF48BBEE0704DA CRC64;
MGLAGTKVKQ RFGLDPRNTS WSNDKSRFGH RYLESMGWAP GKGLGLVEHA TTTHVKVSVK
DDTVGLGAKL AKRSGTDDLE TDSSGLDDFQ RILGRLNGRG REVDEALEQK RKDNIINGKW
GMHFIKGEVL CSTWDRKSKS HMLKTALEDE SEVNFKSSKK RRQSGSEPSR DSTSHAKRMR
GDESKKSTRD QSKQERKEKK IKTEKKEKKE KKEKKEKKEK KEKKEKKEKK EKKERDYGNR
ASPVEPRKHD QISNVGRLSA RAKYIKQKRA SVMDAKALNE IFMISK
