ID   PXR1_YARLI              Reviewed;         292 AA.
AC   Q6C1L3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Protein PXR1;
DE   AltName: Full=PinX1-related protein 1;
GN   Name=PXR1; OrderedLocusNames=YALI0F15235g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC       regulates negatively telomerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78258.1; -; Genomic_DNA.
DR   RefSeq; XP_505449.1; XM_505449.1.
DR   AlphaFoldDB; Q6C1L3; -.
DR   STRING; 4952.CAG78258; -.
DR   PRIDE; Q6C1L3; -.
DR   EnsemblFungi; CAG78258; CAG78258; YALI0_F15235g.
DR   GeneID; 2908653; -.
DR   KEGG; yli:YALI0F15235g; -.
DR   VEuPathDB; FungiDB:YALI0_F15235g; -.
DR   HOGENOM; CLU_052839_0_0_1; -.
DR   InParanoid; Q6C1L3; -.
DR   OMA; WDQSSEA; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0090069; P:regulation of ribosome biogenesis; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR000467; G_patch_dom.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..292
FT                   /note="Protein PXR1"
FT                   /id="PRO_0000324898"
FT   DOMAIN          25..74
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..195
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..246
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  33199 MW;  BCC5E47090A8338E CRC64;
     MGLAGVSKKI KYGKDPRNLG WSNNTERFGH KHMSKLGWKD GEGLGHEDRK AQSITQNIKI
     VLKDDNVGLG AGLAKADKDE AFGLMDFQKL LGKLNGRAQE IEAEVERQQK DVLRGKFGMV
     FVSGGLLQGT IEEFNKKRGS EAVEESDSDS EESESESDDD KKSRKSSKKE KKDKKSKKRK
     ADDDSDEEEK KSKKSKKDKK EKKEKKEKKE KKEKKEKKEK KEKKDKKEKK DKKEKKDKKS
     ESPTPHDGME KPSASSTSAL RGRMAGRAKF IRSKRMAVMD EKSLNEIFMV KN