ID   PXR1_YEAS7              Reviewed;         271 AA.
AC   A6ZUT6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Protein PXR1;
DE   AltName: Full=G-patch nucleolar protein;
DE   AltName: Full=PinX1-related protein 1;
GN   Name=PXR1; Synonyms=GNO1; ORFNames=SCY_2169;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites through
CC       its action in U18 and U24 snoRNA 3'-end final trimming. Negative
CC       regulator of telomerase throughX competition for binding to EST2 with
CC       TLC1 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with EST2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
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DR   EMBL; AAFW02000100; EDN61863.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZUT6; -.
DR   PRIDE; A6ZUT6; -.
DR   EnsemblFungi; EDN61863; EDN61863; SCY_2169.
DR   HOGENOM; CLU_052839_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR000467; G_patch_dom.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..271
FT                   /note="Protein PXR1"
FT                   /id="PRO_0000324899"
FT   DOMAIN          25..72
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          147..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..206
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..225
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         230
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53335"
SQ   SEQUENCE   271 AA;  31388 MW;  5921A61E4DC15CA1 CRC64;
     MGLAATRTKQ RFGLDPRNTA WSNDTSRFGH QFLEKFGWKP GMGLGLYPMN SNTSHIKVSI
     KDDNVGLGAK LKRKDKKDEF DNGECAGLDV FQRILGRLNG KESKISEELD TQRKQKIIDG
     KWGIHFVKGE VLASTWDPKT HKLRNYSNAK KRKREGDDSE DEDDDDKEDK DSDKKKHKKH
     KKHKKDKKKD KKDKKEHKKH KKEEKRLKKE KRAEKTKETK KTSKLKSSES ASNIPDAVNT
     RLSVRSKWIK QKRAALMDSK ALNEIFMITN D