PXT1_HUMAN
ID PXT1_HUMAN Reviewed; 134 AA.
AC Q8NFP0; J3KR74;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Peroxisomal testis-specific protein 1;
DE AltName: Full=Small testis-specific peroxisomal protein;
GN Name=PXT1; Synonyms=STEPP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 77-134.
RC TISSUE=Testis;
RX PubMed=18160785; DOI=10.1159/000109622;
RA Grzmil P., Burfeind C., Preuss T., Dixkens C., Wolf S., Engel W.,
RA Burfeind P.;
RT "The putative peroxisomal gene Pxt1 is exclusively expressed in the
RT testis.";
RL Cytogenet. Genome Res. 119:74-82(2007).
CC -!- INTERACTION:
CC Q8NFP0; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12017894, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-40 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH31105.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI07050.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAN03789.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL133263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL136135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z84484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03891.1; -; Genomic_DNA.
DR EMBL; BC031105; AAH31105.1; ALT_INIT; mRNA.
DR EMBL; BC107049; AAI07050.1; ALT_INIT; mRNA.
DR EMBL; AF486827; AAN03789.1; ALT_INIT; mRNA.
DR CCDS; CCDS4820.2; -.
DR RefSeq; NP_694535.2; NM_152990.3.
DR AlphaFoldDB; Q8NFP0; -.
DR BioGRID; 128810; 1.
DR IntAct; Q8NFP0; 1.
DR STRING; 9606.ENSP00000419944; -.
DR iPTMnet; Q8NFP0; -.
DR PhosphoSitePlus; Q8NFP0; -.
DR BioMuta; PXT1; -.
DR PaxDb; Q8NFP0; -.
DR PRIDE; Q8NFP0; -.
DR Antibodypedia; 29675; 28 antibodies from 13 providers.
DR DNASU; 222659; -.
DR Ensembl; ENST00000454782.3; ENSP00000419944.1; ENSG00000179165.12.
DR GeneID; 222659; -.
DR KEGG; hsa:222659; -.
DR MANE-Select; ENST00000454782.3; ENSP00000419944.1; NM_152990.4; NP_694535.2.
DR UCSC; uc003omd.3; human.
DR CTD; 222659; -.
DR DisGeNET; 222659; -.
DR GeneCards; PXT1; -.
DR HGNC; HGNC:18312; PXT1.
DR HPA; ENSG00000179165; Tissue enriched (testis).
DR neXtProt; NX_Q8NFP0; -.
DR OpenTargets; ENSG00000179165; -.
DR PharmGKB; PA134958920; -.
DR VEuPathDB; HostDB:ENSG00000179165; -.
DR eggNOG; ENOG502RU1V; Eukaryota.
DR GeneTree; ENSGT00390000012893; -.
DR HOGENOM; CLU_1911536_0_0_1; -.
DR InParanoid; Q8NFP0; -.
DR OMA; TIVCEPK; -.
DR OrthoDB; 1461171at2759; -.
DR PhylomeDB; Q8NFP0; -.
DR TreeFam; TF338547; -.
DR PathwayCommons; Q8NFP0; -.
DR SignaLink; Q8NFP0; -.
DR BioGRID-ORCS; 222659; 10 hits in 1058 CRISPR screens.
DR GenomeRNAi; 222659; -.
DR Pharos; Q8NFP0; Tdark.
DR PRO; PR:Q8NFP0; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8NFP0; protein.
DR Bgee; ENSG00000179165; Expressed in right testis and 63 other tissues.
DR ExpressionAtlas; Q8NFP0; baseline and differential.
DR Genevisible; Q8NFP0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IBA:GO_Central.
DR InterPro; IPR029186; PXT1.
DR PANTHER; PTHR40381; PTHR40381; 1.
DR Pfam; PF15214; PXT1; 1.
PE 1: Evidence at protein level;
KW Peroxisome; Reference proteome.
FT CHAIN 1..134
FT /note="Peroxisomal testis-specific protein 1"
FT /id="PRO_0000324593"
FT MOTIF 131..134
FT /note="Microbody targeting signal"
FT /evidence="ECO:0000250"
FT CONFLICT 98
FT /note="V -> A (in Ref. 3; AAH31105)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 134 AA; 16023 MW; 5E65ACEFFFA4074D CRC64;
MKKKHDGIVY ETKEVLNPSP KVTHCCKSLW LKYSFQKAYM TQLVSSQPVP AMSRNPDHNL
LSQPKEHSIV QKHHQEEIIH KLAMQLRHIG DNIDHRMVRE DLQQDGRDAL DHFVFFFFRR
VQVLLHFFWN NHLL
