PXT1_MOUSE
ID PXT1_MOUSE Reviewed; 51 AA.
AC Q8K459;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Peroxisomal testis-specific protein 1;
DE AltName: Full=Small testis-specific peroxisomal protein;
GN Name=Pxt1; Synonyms=Stepp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, AND MUTAGENESIS OF 48-ASN--LEU-50.
RC STRAIN=129/Sv; TISSUE=Testis;
RX PubMed=18160785; DOI=10.1159/000109622;
RA Grzmil P., Burfeind C., Preuss T., Dixkens C., Wolf S., Engel W.,
RA Burfeind P.;
RT "The putative peroxisomal gene Pxt1 is exclusively expressed in the
RT testis.";
RL Cytogenet. Genome Res. 119:74-82(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:18160785}.
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:18160785}.
CC -!- DEVELOPMENTAL STAGE: During spermatogenesis, it is first detected in
CC testis at 15 days postpartum (dpp). Expressed at higher level at 17
CC dpp, 20 dpp, 25 dpp and in adult testis. First expressed when primary
CC spermatocytes are present in postnatal mouse testis.
CC {ECO:0000269|PubMed:18160785}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF486826; AAN03788.1; -; mRNA.
DR EMBL; BC100437; AAI00438.1; -; mRNA.
DR CCDS; CCDS37534.1; -.
DR RefSeq; NP_700439.1; NM_153390.1.
DR AlphaFoldDB; Q8K459; -.
DR STRING; 10090.ENSMUSP00000053366; -.
DR PhosphoSitePlus; Q8K459; -.
DR PaxDb; Q8K459; -.
DR PRIDE; Q8K459; -.
DR Antibodypedia; 29675; 28 antibodies from 13 providers.
DR DNASU; 69307; -.
DR Ensembl; ENSMUST00000051526; ENSMUSP00000053366; ENSMUSG00000045378.
DR GeneID; 69307; -.
DR KEGG; mmu:69307; -.
DR UCSC; uc008brv.1; mouse.
DR CTD; 222659; -.
DR MGI; MGI:1916557; Pxt1.
DR VEuPathDB; HostDB:ENSMUSG00000045378; -.
DR eggNOG; ENOG502RU1V; Eukaryota.
DR GeneTree; ENSGT00390000012893; -.
DR HOGENOM; CLU_211143_0_0_1; -.
DR InParanoid; Q8K459; -.
DR OrthoDB; 1461171at2759; -.
DR PhylomeDB; Q8K459; -.
DR TreeFam; TF338547; -.
DR BioGRID-ORCS; 69307; 2 hits in 69 CRISPR screens.
DR ChiTaRS; Pxt1; mouse.
DR PRO; PR:Q8K459; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8K459; protein.
DR Bgee; ENSMUSG00000045378; Expressed in animal zygote and 47 other tissues.
DR ExpressionAtlas; Q8K459; baseline and differential.
DR Genevisible; Q8K459; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005777; C:peroxisome; IDA:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IGI:MGI.
DR GO; GO:0007283; P:spermatogenesis; IEP:UniProtKB.
DR InterPro; IPR029186; PXT1.
DR PANTHER; PTHR40381; PTHR40381; 1.
DR Pfam; PF15214; PXT1; 1.
PE 1: Evidence at protein level;
KW Peroxisome; Reference proteome.
FT CHAIN 1..51
FT /note="Peroxisomal testis-specific protein 1"
FT /id="PRO_0000324594"
FT MOTIF 48..51
FT /note="Microbody targeting signal"
FT MUTAGEN 48..50
FT /note="NHL->WQK: Abolishes peroxisome localization."
FT /evidence="ECO:0000269|PubMed:18160785"
SQ SEQUENCE 51 AA; 5934 MW; 5EB06461D1C99CDD CRC64;
MQLRHIGDSV NHRVIQEHLA QEVGDVLAPF VALVFVRGQV LLRFFWNNHL L
