ID   PYEL1_METAC             Reviewed;         204 AA.
AC   P58862;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=PyrE-like protein 1;
GN   OrderedLocusNames=MA_0919;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
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DR   EMBL; AE010299; AAM04352.1; -; Genomic_DNA.
DR   RefSeq; WP_011020957.1; NC_003552.1.
DR   AlphaFoldDB; P58862; -.
DR   SMR; P58862; -.
DR   STRING; 188937.MA_0919; -.
DR   EnsemblBacteria; AAM04352; AAM04352; MA_0919.
DR   GeneID; 1472809; -.
DR   KEGG; mac:MA_0919; -.
DR   HOGENOM; CLU_111001_0_0_2; -.
DR   InParanoid; P58862; -.
DR   OMA; DIHVDWS; -.
DR   OrthoDB; 77963at2157; -.
DR   PhylomeDB; P58862; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0019856; P:pyrimidine nucleobase biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006222; P:UMP biosynthetic process; IBA:GO_Central.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_01214; PyrE_like; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR022854; PyrE-like.
DR   PANTHER; PTHR19278:SF41; PTHR19278:SF41; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase.
FT   CHAIN           1..204
FT                   /note="PyrE-like protein 1"
FT                   /id="PRO_0000110808"
SQ   SEQUENCE   204 AA;  21953 MW;  CB5FEDF357EA6F79 CRC64;
     MKNIEDLIQK AVELQNNGLV TGQIADELNV SRETVTWLLT RSKKEVAVPA PKDISVNWSS
     IGKSATRLHY ISLALCDMVL ETLEKTNAEV DVVVGVAASG IPLASMMANE LGADFALYHS
     RKGQDVVQPG QKGTISRNFG SVVGKNCVIV DDVITTGSTT MEVIEQLREM GAKPRVVAVL
     VDKKGADTIA NVPIQSLVRI VRVD