ID   PYEL2_METAC             Reviewed;         203 AA.
AC   P58863;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=PyrE-like protein 2;
GN   OrderedLocusNames=MA_2520;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE010299; AAM05903.1; -; Genomic_DNA.
DR   RefSeq; WP_011022488.1; NC_003552.1.
DR   AlphaFoldDB; P58863; -.
DR   SMR; P58863; -.
DR   STRING; 188937.MA_2520; -.
DR   EnsemblBacteria; AAM05903; AAM05903; MA_2520.
DR   GeneID; 1474409; -.
DR   KEGG; mac:MA_2520; -.
DR   HOGENOM; CLU_111001_0_0_2; -.
DR   InParanoid; P58863; -.
DR   OMA; ASMMAYE; -.
DR   OrthoDB; 77963at2157; -.
DR   PhylomeDB; P58863; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0019856; P:pyrimidine nucleobase biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006222; P:UMP biosynthetic process; IBA:GO_Central.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_01214; PyrE_like; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR022854; PyrE-like.
DR   PANTHER; PTHR19278:SF41; PTHR19278:SF41; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase.
FT   CHAIN           1..203
FT                   /note="PyrE-like protein 2"
FT                   /id="PRO_0000110809"
SQ   SEQUENCE   203 AA;  22130 MW;  57FDD83CBEABC899 CRC64;
     MKDIEDLIEK AVELQSNGLI SAQIADELNI SRETVTWLLT RSKKEEATPA PKDISVDWSS
     IGKSAKRLHN ISLALCDMVL ETMEKVNAEV DVVVGIAANG VPLASMMAYE LDADFAIYHR
     KGQGIVHAGH RGTISRNFGS VAGKNCIIVD DVITTGSTSM EVIEQLKEMD AKPRVVTVLV
     DKKGVDTIYN VPIQSLVRIA RVD