ID   PYM1_XENTR              Reviewed;         200 AA.
AC   B1WB17; B7ZSP7;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Partner of Y14 and mago {ECO:0000250|UniProtKB:P82804};
DE   AltName: Full=PYM homolog 1 exon junction complex-associated factor {ECO:0000250|UniProtKB:Q9BRP8};
DE   AltName: Full=Protein wibg homolog;
GN   Name=pym1 {ECO:0000250|UniProtKB:Q9BRP8}; Synonyms=pym, wibg;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Neurula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key regulator of the exon junction complex (EJC), a
CC       multiprotein complex that associates immediately upstream of the exon-
CC       exon junction on mRNAs and serves as a positional landmark for the
CC       intron exon structure of genes and directs post-transcriptional
CC       processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA
CC       decay (NMD) or translation. Acts as an EJC disassembly factor, allowing
CC       translation-dependent EJC removal and recycling by disrupting mature
CC       EJC from spliced mRNAs. Its association with the 40S ribosomal subunit
CC       probably prevents a translation-independent disassembly of the EJC from
CC       spliced mRNAs, by restricting its activity to mRNAs that have been
CC       translated. Interferes with NMD and enhances translation of spliced
CC       mRNAs, probably by antagonizing EJC functions (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with magoh and rbm8a; the
CC       interaction is direct. Associates (eIF2A-like region) with the 40S
CC       ribosomal subunit and the 48S preinitiation complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BRP8}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9BRP8}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q9BRP8}. Note=Shuttles between the nucleus and
CC       the cytoplasm. Nuclear export is mediated by XPO1/CRM1.
CC       {ECO:0000250|UniProtKB:Q9BRP8}.
CC   -!- SIMILARITY: Belongs to the pym family. {ECO:0000305}.
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DR   EMBL; BC161580; AAI61580.1; -; mRNA.
DR   EMBL; BC170597; AAI70597.1; -; mRNA.
DR   EMBL; BC170601; AAI70601.1; -; mRNA.
DR   RefSeq; NP_001016274.1; NM_001016274.2.
DR   AlphaFoldDB; B1WB17; -.
DR   SMR; B1WB17; -.
DR   STRING; 8364.ENSXETP00000047260; -.
DR   PaxDb; B1WB17; -.
DR   GeneID; 549028; -.
DR   KEGG; xtr:549028; -.
DR   CTD; 84305; -.
DR   Xenbase; XB-GENE-943122; pym1.
DR   eggNOG; KOG4325; Eukaryota.
DR   HOGENOM; CLU_074603_3_0_1; -.
DR   InParanoid; B1WB17; -.
DR   OrthoDB; 1545729at2759; -.
DR   TreeFam; TF324615; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0035145; C:exon-exon junction complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:1903259; P:exon-exon junction complex disassembly; IBA:GO_Central.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   GO; GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
DR   InterPro; IPR039333; PYM1.
DR   InterPro; IPR015362; WIBG_mago-bd.
DR   InterPro; IPR036348; WIBG_N_sf.
DR   PANTHER; PTHR22959; PTHR22959; 1.
DR   Pfam; PF09282; Mago-bind; 1.
DR   SMART; SM01273; Mago-bind; 1.
DR   SUPFAM; SSF101931; SSF101931; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus;
KW   Reference proteome; Translation regulation.
FT   CHAIN           1..200
FT                   /note="Partner of Y14 and mago"
FT                   /id="PRO_0000378158"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          52..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          84..200
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        60..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        146
FT                   /note="K -> R (in Ref. 1; AAI70601/AAI70597)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   200 AA;  22854 MW;  8BEA0CE8FA904C53 CRC64;
     MATPYVTDES GKYIAATQRP DGSWRKQRKV KEGYVPQEEV PVYENKYVKF FKSKPSLPPG
     LSETDASTGK TQQPSKPDAD TTLSKTAKRN MKRKEKRKQE KGEREQVEDA RQDLERVNIS
     ETPVQKNLTS AHKNGSASSD NPAAEKAKKI KNLRKKLRQV EELQQKIDSG EIKEPSKEQL
     EKLSRRKALE EEIEDLELDL