位置:首页 > 蛋白库 > PYM_AEDAE
PYM_AEDAE
ID   PYM_AEDAE               Reviewed;         253 AA.
AC   Q16LW2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Partner of Y14 and mago {ECO:0000250|UniProtKB:P82804};
DE   AltName: Full=Protein wibg homolog;
GN   Name=Pym {ECO:0000250|UniProtKB:P82804}; Synonyms=wibg;
GN   ORFNames=AAEL012503;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Regulator of the exon junction complex (EJC), a multiprotein
CC       complex that associates immediately upstream of the exon-exon junction
CC       on mRNAs and serves as a positional landmarks for the intron exon
CC       structure of genes and directs post-transcriptional processes in the
CC       cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or
CC       translation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with mago and tsu/Y14; the
CC       interaction is direct. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is
CC       mediated by emb/Crm1 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pym family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH477889; EAT35312.1; -; Genomic_DNA.
DR   RefSeq; XP_001656113.1; XM_001656063.1.
DR   AlphaFoldDB; Q16LW2; -.
DR   SMR; Q16LW2; -.
DR   STRING; 7159.AAEL012503-PA; -.
DR   GeneID; 5576411; -.
DR   KEGG; aag:5576411; -.
DR   VEuPathDB; VectorBase:AAEL012503; -.
DR   eggNOG; KOG4325; Eukaryota.
DR   HOGENOM; CLU_074603_3_0_1; -.
DR   InParanoid; Q16LW2; -.
DR   OMA; MAKLESW; -.
DR   OrthoDB; 1363113at2759; -.
DR   PhylomeDB; Q16LW2; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035145; C:exon-exon junction complex; ISS:UniProtKB.
DR   GO; GO:1903259; P:exon-exon junction complex disassembly; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR039333; PYM1.
DR   InterPro; IPR015362; WIBG_mago-bd.
DR   InterPro; IPR036348; WIBG_N_sf.
DR   PANTHER; PTHR22959; PTHR22959; 1.
DR   Pfam; PF09282; Mago-bind; 1.
DR   SMART; SM01273; Mago-bind; 1.
DR   SUPFAM; SSF101931; SSF101931; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..253
FT                   /note="Partner of Y14 and mago"
FT                   /id="PRO_0000378159"
FT   REGION          1..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          129..156
FT                   /evidence="ECO:0000255"
FT   COILED          189..221
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   253 AA;  29140 MW;  AD36B822C6A0F1B8 CRC64;
     MTTYATDSQG KFIPSTQRPD GTWRKPRRVR DGYVPQEEVP LYESKGKLFA QKPLLPPGMS
     PEMAQKSREK REREQRIKQQ READANRRPP QNPVPGLLIL NGDSKINQPQ QRAAKSAKPK
     KKAVELPDVL LEQKQKEEQK QVRQQQQQQK SQKDHKNTKP HHQERIEEVA KAMNGLQLTN
     NHVASASAAD ALQTDLSKKL RKLRKKIREI EIIEERLRST DGGPRPDKDQ IDKAKRKPEI
     LKEIEELEKG IAK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024