PYM_ANOGA
ID PYM_ANOGA Reviewed; 233 AA.
AC Q7Q6B5;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 4.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Partner of Y14 and mago {ECO:0000250|UniProtKB:P82804};
DE AltName: Full=Protein wibg homolog;
GN Name=Pym {ECO:0000250|UniProtKB:P82804}; Synonyms=wibg;
GN ORFNames=AGAP005936;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Regulator of the exon junction complex (EJC), a multiprotein
CC complex that associates immediately upstream of the exon-exon junction
CC on mRNAs and serves as a positional landmarks for the intron exon
CC structure of genes and directs post-transcriptional processes in the
CC cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or
CC translation. {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via N-terminus) with mago and tsu/Y14; the
CC interaction is direct. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is
CC mediated by emb/Crm1 (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the pym family. {ECO:0000305}.
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DR EMBL; AAAB01008960; EAA11365.4; -; Genomic_DNA.
DR RefSeq; XP_315966.4; XM_315966.4.
DR AlphaFoldDB; Q7Q6B5; -.
DR SMR; Q7Q6B5; -.
DR STRING; 7165.AGAP005936-PA; -.
DR PaxDb; Q7Q6B5; -.
DR GeneID; 1276603; -.
DR KEGG; aga:AgaP_AGAP005936; -.
DR CTD; 1276603; -.
DR VEuPathDB; VectorBase:AGAP005936; -.
DR eggNOG; KOG4325; Eukaryota.
DR HOGENOM; CLU_074603_3_0_1; -.
DR InParanoid; Q7Q6B5; -.
DR OMA; IPGCADS; -.
DR OrthoDB; 1363113at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0035145; C:exon-exon junction complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:1903259; P:exon-exon junction complex disassembly; IBA:GO_Central.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR InterPro; IPR039333; PYM1.
DR InterPro; IPR015362; WIBG_mago-bd.
DR InterPro; IPR036348; WIBG_N_sf.
DR PANTHER; PTHR22959; PTHR22959; 1.
DR Pfam; PF09282; Mago-bind; 1.
DR SMART; SM01273; Mago-bind; 1.
DR SUPFAM; SSF101931; SSF101931; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..233
FT /note="Partner of Y14 and mago"
FT /id="PRO_0000378160"
FT REGION 1..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 62..97
FT /evidence="ECO:0000255"
FT COILED 167..199
FT /evidence="ECO:0000255"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 233 AA; 25688 MW; D2D0AA6EA5AA5056 CRC64;
MTTYSTDSQG KFIPATQRPD GTWRKPRRVR DGYVPQEEVP LYESKGKQFA QKPALPPGLS
PEVVQKAKEK RERERLRQAR EEQQRKEQQN KKQQAGALPP GVLAVDGGAV GGNNDKQKPG
AKQPQQHTKS SQQKSTTAAA AAVSNNSDST VDELASALAS GAQLAGADAQ QLEVAKKLRK
LRKKIREIEA IETKLRSTDG PKLDKDQLEK VKRKPDILQE IEELEVQYSA GAM
