PYM_CULQU
ID PYM_CULQU Reviewed; 238 AA.
AC B0WII7;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Partner of Y14 and mago {ECO:0000250|UniProtKB:P82804};
DE AltName: Full=Protein wibg homolog;
GN Name=Pym {ECO:0000250|UniProtKB:P82804}; Synonyms=wibg;
GN ORFNames=CPIJ006916;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulator of the exon junction complex (EJC), a multiprotein
CC complex that associates immediately upstream of the exon-exon junction
CC on mRNAs and serves as a positional landmarks for the intron exon
CC structure of genes and directs post-transcriptional processes in the
CC cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or
CC translation. {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via N-terminus) with mago and tsu/Y14; the
CC interaction is direct. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is
CC mediated by emb/Crm1 (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the pym family. {ECO:0000305}.
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DR EMBL; DS231949; EDS28510.1; -; Genomic_DNA.
DR RefSeq; XP_001848521.1; XM_001848469.1.
DR AlphaFoldDB; B0WII7; -.
DR SMR; B0WII7; -.
DR STRING; 7176.CPIJ006916-PA; -.
DR GeneID; 6038803; -.
DR KEGG; cqu:CpipJ_CPIJ006916; -.
DR VEuPathDB; VectorBase:CPIJ006916; -.
DR VEuPathDB; VectorBase:CQUJHB006611; -.
DR eggNOG; KOG4325; Eukaryota.
DR HOGENOM; CLU_074603_3_0_1; -.
DR InParanoid; B0WII7; -.
DR OMA; MAKLESW; -.
DR OrthoDB; 1363113at2759; -.
DR PhylomeDB; B0WII7; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035145; C:exon-exon junction complex; ISS:UniProtKB.
DR GO; GO:1903259; P:exon-exon junction complex disassembly; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR InterPro; IPR039333; PYM1.
DR InterPro; IPR015362; WIBG_mago-bd.
DR InterPro; IPR036348; WIBG_N_sf.
DR PANTHER; PTHR22959; PTHR22959; 1.
DR Pfam; PF09282; Mago-bind; 1.
DR SMART; SM01273; Mago-bind; 1.
DR SUPFAM; SSF101931; SSF101931; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..238
FT /note="Partner of Y14 and mago"
FT /id="PRO_0000378162"
FT REGION 1..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 176..233
FT /evidence="ECO:0000255"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 238 AA; 26934 MW; E06B49C605F99E7B CRC64;
MTTYATDSQG KFIPATQRPD GTWRKPRRVR DGYVPQEEVP LYESKGKLFA QKPSLPPGLP
PEMAQKAREK REKEQRKAAA RPAQNPVPGL LILHEDNKAN QRQAKPANAK PKKKAVELPD
VLLEQKQKEE QKAASRQQAQ DQRNSKQQQS QNQSKPLDDV TKAVQDLQLG TASGADGHSD
LSKKLRKLRK KIREIEVIEE RLRASDGPRP DKDQIEKAKR KAEILKEIEE LERGGGHK
