PYM_DROSI
ID PYM_DROSI Reviewed; 204 AA.
AC B4NSP6;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Partner of Y14 and mago {ECO:0000250|UniProtKB:P82804};
DE AltName: Full=Protein within the bgcn gene intron;
GN Name=Pym {ECO:0000250|UniProtKB:P82804}; Synonyms=wibg; ORFNames=GD15199;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Regulator of the exon junction complex (EJC), a multiprotein
CC complex that associates immediately upstream of the exon-exon junction
CC on mRNAs and serves as a positional landmarks for the intron exon
CC structure of genes and directs post-transcriptional processes in the
CC cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or
CC translation. {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via N-terminus) with mago and tsu/Y14; the
CC interaction is direct. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is
CC mediated by emb/Crm1 (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the pym family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDX15624.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH982397; EDX15624.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; B4NSP6; -.
DR SMR; B4NSP6; -.
DR STRING; 7240.B4NSP6; -.
DR EnsemblMetazoa; FBtr0349436; FBpp0314276; FBgn0268649.
DR Proteomes; UP000000304; Unassembled WGS sequence.
DR Bgee; FBgn0268649; Expressed in female reproductive system and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035145; C:exon-exon junction complex; ISS:UniProtKB.
DR GO; GO:1990448; F:exon-exon junction complex binding; IEA:EnsemblMetazoa.
DR GO; GO:0003723; F:RNA binding; IEA:EnsemblMetazoa.
DR GO; GO:1903259; P:exon-exon junction complex disassembly; IEA:EnsemblMetazoa.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR InterPro; IPR039333; PYM1.
DR InterPro; IPR015362; WIBG_mago-bd.
DR InterPro; IPR036348; WIBG_N_sf.
DR PANTHER; PTHR22959; PTHR22959; 1.
DR Pfam; PF09282; Mago-bind; 1.
DR SMART; SM01273; Mago-bind; 1.
DR SUPFAM; SSF101931; SSF101931; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..204
FT /note="Partner of Y14 and mago"
FT /id="PRO_0000378163"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 149..181
FT /evidence="ECO:0000255"
FT COMPBIAS 67..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 204 AA; 23066 MW; F13DB592B607F821 CRC64;
MSTYLQSSEG KFIPATKRPD GTWRKARRVK DGYVPQEEVP LYESKGKQFV AQRQAGVPPG
MCPLVAAESK KEREKQERTR AKKQEKESGR QPKAPAPGVL VMPPSTCPPP KVSQQQQQQP
SGSRDINSIS KAMEDTLKLD APQEVVDPAK QLKKLRKKIR EIEQIESRIQ AGEQKKLDKD
QLDKVKKKSE ILRQIKDLES TPRS
