PYRB_DESVH
ID PYRB_DESVH Reviewed; 317 AA.
AC Q727F4;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Aspartate carbamoyltransferase {ECO:0000255|HAMAP-Rule:MF_00001};
DE EC=2.1.3.2 {ECO:0000255|HAMAP-Rule:MF_00001};
DE AltName: Full=Aspartate transcarbamylase {ECO:0000255|HAMAP-Rule:MF_00001};
DE Short=ATCase {ECO:0000255|HAMAP-Rule:MF_00001};
GN Name=pyrB {ECO:0000255|HAMAP-Rule:MF_00001}; OrderedLocusNames=DVU_2901;
OS Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS B-1760 / Hildenborough).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC Desulfovibrionaceae; Desulfovibrio.
OX NCBI_TaxID=882;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough;
RX PubMed=15077118; DOI=10.1038/nbt959;
RA Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M.,
RA Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA Nelson W.C., Sullivan S.A., Fouts D.E., Haft D.H., Selengut J.,
RA Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G.,
RA Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V.,
RA Wall J.D., Voordouw G., Fraser C.M.;
RT "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT Desulfovibrio vulgaris Hildenborough.";
RL Nat. Biotechnol. 22:554-559(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:58228; EC=2.1.3.2; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00001};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC (S)-dihydroorotate from bicarbonate: step 2/3. {ECO:0000255|HAMAP-
CC Rule:MF_00001}.
CC -!- INTERACTION:
CC Q727F4; Q727F3: pyrC; NbExp=4; IntAct=EBI-10066379, EBI-10066383;
CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC superfamily. ATCase family. {ECO:0000255|HAMAP-Rule:MF_00001}.
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DR EMBL; AE017285; AAS97373.1; -; Genomic_DNA.
DR RefSeq; WP_010940161.1; NZ_CABHLV010000001.1.
DR RefSeq; YP_012113.1; NC_002937.3.
DR AlphaFoldDB; Q727F4; -.
DR SMR; Q727F4; -.
DR IntAct; Q727F4; 4.
DR STRING; 882.DVU_2901; -.
DR PaxDb; Q727F4; -.
DR EnsemblBacteria; AAS97373; AAS97373; DVU_2901.
DR KEGG; dvu:DVU_2901; -.
DR PATRIC; fig|882.5.peg.2623; -.
DR eggNOG; COG0540; Bacteria.
DR HOGENOM; CLU_043846_2_0_7; -.
DR OMA; FPTEREY; -.
DR PhylomeDB; Q727F4; -.
DR UniPathway; UPA00070; UER00116.
DR Proteomes; UP000002194; Chromosome.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1370; -; 2.
DR HAMAP; MF_00001; Asp_carb_tr; 1.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR InterPro; IPR002082; Asp_carbamoyltransf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR PANTHER; PTHR11405:SF16; PTHR11405:SF16; 1.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR SUPFAM; SSF53671; SSF53671; 1.
DR TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 1: Evidence at protein level;
KW Pyrimidine biosynthesis; Reference proteome; Transferase.
FT CHAIN 1..317
FT /note="Aspartate carbamoyltransferase"
FT /id="PRO_0000113127"
SQ SEQUENCE 317 AA; 34649 MW; 03CBF75B783F1EFB CRC64;
MQNETRSLWP HKDLLDVDQL SKDELLHLLD TAAQFHEINR RPVKKVPTLK GKSVILFFAE
PSTRTKTSFD VAGKRLSADT FSLAKSGSSL QKGESLKDTA LTLEAMNPDV LVIRHSSSGA
ARFLAERLAC GVVNAGDGWH AHPTQALLDC YSLRQVWGDT FEGRTLCILG DIAHSRVARS
NVKLLTSLGV RVRLCAPRTL LPAGVGNWPV EVFTDLDAAV RDADAVMCLR LQLERQQAGL
LPDLREYSNR YCLTPRRLEL AKPEAKVLHP GPMNRGLEIA SSIADAPASL VLDQVAAGVA
TRMAILFLLA TRTDGGR