位置:首页 > 蛋白库 > PYRB_LACLA
PYRB_LACLA
ID   PYRB_LACLA              Reviewed;         310 AA.
AC   Q9CF79;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=LL1602; ORFNames=L45002;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC         aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58228; EC=2.1.3.2;
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       (S)-dihydroorotate from bicarbonate: step 2/3.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. ATCase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005176; AAK05700.1; -; Genomic_DNA.
DR   PIR; B86825; B86825.
DR   RefSeq; NP_267758.1; NC_002662.1.
DR   RefSeq; WP_003129382.1; NC_002662.1.
DR   AlphaFoldDB; Q9CF79; -.
DR   SMR; Q9CF79; -.
DR   STRING; 272623.L45002; -.
DR   PaxDb; Q9CF79; -.
DR   EnsemblBacteria; AAK05700; AAK05700; L45002.
DR   KEGG; lla:L45002; -.
DR   PATRIC; fig|272623.7.peg.1723; -.
DR   eggNOG; COG0540; Bacteria.
DR   HOGENOM; CLU_043846_2_1_9; -.
DR   OMA; FPTEREY; -.
DR   UniPathway; UPA00070; UER00116.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1370; -; 2.
DR   HAMAP; MF_00001; Asp_carb_tr; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR   InterPro; IPR002082; Asp_carbamoyltransf.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR   PANTHER; PTHR11405:SF16; PTHR11405:SF16; 1.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   SUPFAM; SSF53671; SSF53671; 1.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Pyrimidine biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..310
FT                   /note="Aspartate carbamoyltransferase"
FT                   /id="PRO_0000113145"
SQ   SEQUENCE   310 AA;  34558 MW;  EEDE6B8EC6F00B94 CRC64;
     MSVKNGLVQL ENLTSMEKLS VDEVMGLIKR ASAFKAGTAE FDLEKQTFAS NLFFENSTRT
     HHSFHIAERK LGLDVLEFDA QASSISKGET LYDTVLTLDA LGVDICVIRS GVEHYYEELV
     NSDNIHCAIV NGGDGSGQHP SQCLLDLMTI YEEFGKFEGL KIAISGDLTH SRVAKSNMMM
     LQKLGARLYF TGPAAWYSEE FDDYGHYANL DRILPELDVH MLLRVQHERH DSGESFSKEG
     YHNHFGLTEE RAKMLKPTAI IMHPAPVNRG VEIADSLVES PQSRIVQQMS NGVYTRMAIL
     EAILAGKKAK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024