ID   ATP6_TOBAC              Reviewed;         395 AA.
AC   P05499;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=ATP synthase subunit a;
DE   AltName: Full=F-ATPase protein 6;
GN   Name=ATP6;
OS   Nicotiana tabacum (Common tobacco).
OG   Mitochondrion.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Hicks; TISSUE=Leaf;
RX   PubMed=2896073; DOI=10.1007/bf00419555;
RA   Bland M.M., Levings C.S. III, Matzinger D.F.;
RT   "The ATPase subunit 6 gene of tobacco mitochondria contains an unusual
RT   sequence.";
RL   Curr. Genet. 12:475-481(1987).
CC   -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC       Complex V) produces ATP from ADP in the presence of a proton gradient
CC       across the membrane which is generated by electron transport complexes
CC       of the respiratory chain. F-type ATPases consist of two structural
CC       domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC       - containing the membrane proton channel, linked together by a central
CC       stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC       catalytic domain of F(1) is coupled via a rotary mechanism of the
CC       central stalk subunits to proton translocation. Key component of the
CC       proton channel; it may play a direct role in the translocation of
CC       protons across the membrane.
CC   -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC       - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC       alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main
CC       subunits: a, b and c.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000305}.
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DR   EMBL; X06595; CAA29816.1; -; Genomic_DNA.
DR   PIR; S00651; PWNT6M.
DR   RefSeq; YP_173362.1; NC_006581.1.
DR   AlphaFoldDB; P05499; -.
DR   SMR; P05499; -.
DR   PRIDE; P05499; -.
DR   GeneID; 3205347; -.
DR   KEGG; nta:3205347; -.
DR   OMA; WIAYHVE; -.
DR   OrthoDB; 1095315at2759; -.
DR   Proteomes; UP000084051; Mitochondrion MT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR   Gene3D; 1.20.120.220; -; 1.
DR   HAMAP; MF_01393; ATP_synth_a_bact; 1.
DR   InterPro; IPR000568; ATP_synth_F0_asu.
DR   InterPro; IPR023011; ATP_synth_F0_asu_AS.
DR   InterPro; IPR045083; ATP_synth_F0_asu_bact/mt.
DR   InterPro; IPR035908; F0_ATP_A_sf.
DR   PANTHER; PTHR11410; PTHR11410; 1.
DR   Pfam; PF00119; ATP-synt_A; 1.
DR   PRINTS; PR00123; ATPASEA.
DR   SUPFAM; SSF81336; SSF81336; 1.
DR   TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1.
DR   PROSITE; PS00449; ATPASE_A; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..395
FT                   /note="ATP synthase subunit a"
FT                   /id="PRO_0000082178"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   395 AA;  43504 MW;  70673F8F3D0C781B CRC64;
     MFRRIFLFDE DSLNSSVTSY TNASQSTTTI MDYSLKSSDT QGSSSGIFTD HPGLNPCSER
     IVELQYDIRL KLGALMPKES AQKVLEASEA LHGESNNIAF LEYLLEDLQQ NGVGGEAYKD
     AVDLSKDLVS SPLEQFEIIS LIPMKIGNLY FSFTNPSLFM LLTLSLVLLL VYFVTKKGGG
     NSVPNAWQSL VELIYDFVLN PVNEQIGGLS GNVKQKFSPR ISVTFTFSLF CNPQGMIPYS
     FTVTSHFLIT LGLSFSIFIG ITIVGFQKNG LHFLSFLLPA GVPLPLAPFL VLLELIPYCF
     RALSSGIRLF ANMMAGHSSV KILSGFAWTM LCMNDLLYFI GDLGPLFIVL ALTGLELGVA
     ISQAHVSTIL ICIYLNDAIN LHQSASFFII EQKRV