ID   PYRC1_PYRCO             Reviewed;         159 AA.
AC   O65200;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Major allergen Pyr c 1;
DE   AltName: Allergen=Pyr c 1;
GN   Name=PYRC1;
OS   Pyrus communis (Pear) (Pyrus domestica).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Pyrus.
OX   NCBI_TaxID=23211;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Williams;
RX   PubMed=11419719; DOI=10.1016/s0378-4347(01)00087-1;
RA   Karamloo F., Scheurer S., Wangorsch A., May S., Haustein D., Vieths S.;
RT   "Pyr c 1, the major allergen from pear (Pyrus communis), is a new member of
RT   the Bet v 1 allergen family.";
RL   J. Chromatogr. B 756:281-293(2001).
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
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DR   EMBL; AF057030; AAC13315.1; -; mRNA.
DR   AlphaFoldDB; O65200; -.
DR   SMR; O65200; -.
DR   Allergome; 3457; Pyr c 1.0101.
DR   Allergome; 607; Pyr c 1.
DR   GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR000916; Bet_v_I/MLP.
DR   InterPro; IPR024949; Bet_v_I_allergen.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF00407; Bet_v_1; 1.
DR   PRINTS; PR00634; BETALLERGEN.
DR   PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE   1: Evidence at protein level;
KW   Allergen; Pathogenesis-related protein; Plant defense.
FT   CHAIN           1..159
FT                   /note="Major allergen Pyr c 1"
FT                   /id="PRO_0000154203"
SQ   SEQUENCE   159 AA;  17581 MW;  DE42BBB4FBD6F4D3 CRC64;
     MGLYTFENEF TSEIPPPRLF KAFVLDADNL IPKIAPQAIK HAEILEGNGG PGTIKKITFG
     EGSQYGYVKH RVDSIDEASY SYAYTLIEGD ALTDTIEKIS YEAKLVASGS GSTIKSISHY
     HTKGDIEIKE EHVKAGKEKA HGLFKLIESY LKDHPDAYN