ID   PYRD1_DICDI             Reviewed;         546 AA.
AC   Q54H36;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1;
DE            EC=1.8.1.-;
GN   Name=pyroxd1; ORFNames=DDB_G0289727;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide
CC       oxidoreductase family. PYROXD1 subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000148; EAL62575.1; -; Genomic_DNA.
DR   RefSeq; XP_636082.1; XM_630990.1.
DR   AlphaFoldDB; Q54H36; -.
DR   SMR; Q54H36; -.
DR   STRING; 44689.DDB0305028; -.
DR   PaxDb; Q54H36; -.
DR   EnsemblProtists; EAL62575; EAL62575; DDB_G0289727.
DR   GeneID; 8627294; -.
DR   KEGG; ddi:DDB_G0289727; -.
DR   dictyBase; DDB_G0289727; pyroxd1.
DR   eggNOG; KOG2755; Eukaryota.
DR   HOGENOM; CLU_026335_0_0_1; -.
DR   InParanoid; Q54H36; -.
DR   OMA; MCENLIL; -.
DR   PhylomeDB; Q54H36; -.
DR   PRO; PR:Q54H36; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.390.30; -; 1.
DR   Gene3D; 3.50.50.60; -; 3.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR   Pfam; PF07992; Pyr_redox_2; 2.
DR   SUPFAM; SSF51905; SSF51905; 2.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..546
FT                   /note="Pyridine nucleotide-disulfide oxidoreductase domain-
FT                   containing protein 1"
FT                   /id="PRO_0000327424"
SQ   SEQUENCE   546 AA;  61999 MW;  350058059F10C110 CRC64;
     MTINQLIVIG GGIAGLTCAE SYSHLKPNDK VTILSCSPIL KTVCNVQKIS KVLESFEVFE
     TQFTDIEFKN PNISVIICDV DSIDINNRIV KTDKGNFKYD YLSICSGAKP NLVKESPYLI
     GIRDTETIVD LKNRLSNAKR IVIVGNGGIA LELIHEIKNC QIIWSIKDKH IGNAFFDKDA
     ADFLFRSKQI IDDDNHDKKN VVKEQQQQQQ KDGILLNEDE LIAKNQNISS QSNSSLYKSE
     SGSALGPQWY SKYNFKTTDQ YNKNNQEKKY NFNENVNIQY STFLDEIYSN HDKKLNQEII
     NNNNNGDGDD KEDWPIYVKL SNGNLFGCNF IISATGVIPN STILTKDNNN NNNNKIIKLS
     NEGAIIVDEQ MKTSVDRIYS AGDVCSIEWS ESEVWFQMRL WSQARTQGRY TAQCIANESV
     KNTPQQDNLD QICTNFEFEL FAHATKFFGF KVIMLGLYNA QGLNLNLDNN NQNEENQDNI
     KIYTREIIGE QYVKVILKNG RLIGSLLIGD TDLEETFENL ILNQIDLSGY GAEILNPEID
     IEDYFD