ID   PYRD1_RAT               Reviewed;         498 AA.
AC   Q68FS6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1;
DE            EC=1.8.1.-;
GN   Name=Pyroxd1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable FAD-dependent oxidoreductase; involved in the
CC       cellular oxidative stress response (By similarity). Required for normal
CC       sarcomere structure and muscle fiber integrity (By similarity).
CC       {ECO:0000250|UniProtKB:Q6PBT5, ECO:0000250|UniProtKB:Q8WU10}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000250|UniProtKB:O52582};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250|UniProtKB:O52582};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WU10}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q3TMV7}. Cytoplasm, myofibril, sarcomere
CC       {ECO:0000250|UniProtKB:Q8WU10}.
CC   -!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide
CC       oxidoreductase family. PYROXD1 subfamily. {ECO:0000305}.
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DR   EMBL; BC079377; AAH79377.1; -; mRNA.
DR   RefSeq; NP_001004234.1; NM_001004234.1.
DR   AlphaFoldDB; Q68FS6; -.
DR   SMR; Q68FS6; -.
DR   STRING; 10116.ENSRNOP00000016794; -.
DR   iPTMnet; Q68FS6; -.
DR   PhosphoSitePlus; Q68FS6; -.
DR   PaxDb; Q68FS6; -.
DR   GeneID; 297708; -.
DR   KEGG; rno:297708; -.
DR   UCSC; RGD:1303253; rat.
DR   CTD; 79912; -.
DR   RGD; 1303253; Pyroxd1.
DR   eggNOG; KOG2755; Eukaryota.
DR   InParanoid; Q68FS6; -.
DR   OrthoDB; 1463391at2759; -.
DR   PhylomeDB; Q68FS6; -.
DR   PRO; PR:Q68FS6; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030017; C:sarcomere; ISS:UniProtKB.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0034599; P:cellular response to oxidative stress; ISS:UniProtKB.
DR   Gene3D; 3.30.390.30; -; 1.
DR   Gene3D; 3.50.50.60; -; 3.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR   InterPro; IPR041575; Rubredoxin_C.
DR   Pfam; PF07992; Pyr_redox_2; 2.
DR   Pfam; PF18267; Rubredoxin_C; 1.
DR   SUPFAM; SSF51905; SSF51905; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; FAD; Flavoprotein; NADP; Nucleus; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..498
FT                   /note="Pyridine nucleotide-disulfide oxidoreductase domain-
FT                   containing protein 1"
FT                   /id="PRO_0000327422"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WU10"
SQ   SEQUENCE   498 AA;  55490 MW;  320BDA30A6675AB6 CRC64;
     MEAARPAGTF VVVGGGIAGV TCAEQLAINF PAEDILLVTA SPVIKAVTNF KQVSKVLEEF
     DVEEQPSTML ENRFPNIKVI ESGVKQLKSD KHCIFTEDGR EYVYKKLCLC AGAKPKLICE
     GNPYVLGIRD TDSAQEFQKQ LTKARRIMIV GNGGIALELA YEVEVCEVIW AIKDKAIGNT
     FFDAGAAEFL TSRLLSEKSE AKLAHKRTIY TVEEAKKETS TKSKADYVGS ALGPDWHGGL
     ALKGTEEFSH SIHIETKCEV KKIYLQEEFK IMKKKSLAFP KDHHKSVTVD KEMWPVYVEL
     TNGSIYGCDF LVSATGVTPN VQPFLHGNDF DLGEDGGLRV DEQMRTSLPD IYAAGDICTA
     CWPPSPVWQQ MRLWTQARQM GCYAAKCMAA ATMGHPIDMD FSFELFAHVT KFFNYKVVLL
     GKYNAQGLGV DHELMLRCTR GQEYIKVVMH NGRMMGAVLI GETDLEETFE NLILNQMDLS
     SYGEDLLNPD IDIEDYFD