PYRD2_MOUSE
ID PYRD2_MOUSE Reviewed; 581 AA.
AC Q3U4I7; E9QPD2; Q8CAN2; Q9D630;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 3.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 {ECO:0000305};
DE EC=1.-.-.-;
GN Name=Pyroxd2 {ECO:0000312|MGI:MGI:1921830};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Head, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable oxidoreductase that may play a role as regulator of
CC mitochondrial function. {ECO:0000250|UniProtKB:Q8N2H3}.
CC -!- SUBUNIT: Interacts with COX5B; this interaction may contribute to
CC localize PYROXD2 to the inner face of the inner mitochondrial membrane.
CC {ECO:0000250|UniProtKB:Q8N2H3}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:Q8N2H3}. Note=The import into mitochondria is
CC dependent on TOMM40 and TIMM23. {ECO:0000250|UniProtKB:Q8N2H3}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE32444.1; Type=Miscellaneous discrepancy; Note=Intron retention between positions 50 and 165.; Evidence={ECO:0000305};
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DR EMBL; AK014668; BAB29495.1; -; mRNA.
DR EMBL; AK038414; BAC29991.1; -; mRNA.
DR EMBL; AK154222; BAE32444.1; ALT_SEQ; mRNA.
DR EMBL; AC125458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS37991.1; -.
DR RefSeq; NP_083287.2; NM_029011.2.
DR AlphaFoldDB; Q3U4I7; -.
DR SMR; Q3U4I7; -.
DR STRING; 10090.ENSMUSP00000075825; -.
DR iPTMnet; Q3U4I7; -.
DR PhosphoSitePlus; Q3U4I7; -.
DR jPOST; Q3U4I7; -.
DR MaxQB; Q3U4I7; -.
DR PaxDb; Q3U4I7; -.
DR PeptideAtlas; Q3U4I7; -.
DR PRIDE; Q3U4I7; -.
DR ProteomicsDB; 300296; -.
DR Antibodypedia; 31034; 99 antibodies from 19 providers.
DR Ensembl; ENSMUST00000076505; ENSMUSP00000075825; ENSMUSG00000060224.
DR GeneID; 74580; -.
DR KEGG; mmu:74580; -.
DR UCSC; uc008hnu.1; mouse.
DR CTD; 84795; -.
DR MGI; MGI:1921830; Pyroxd2.
DR VEuPathDB; HostDB:ENSMUSG00000060224; -.
DR eggNOG; KOG4254; Eukaryota.
DR GeneTree; ENSGT00390000011684; -.
DR HOGENOM; CLU_019327_0_0_1; -.
DR InParanoid; Q3U4I7; -.
DR OMA; GMQGAWG; -.
DR OrthoDB; 392025at2759; -.
DR PhylomeDB; Q3U4I7; -.
DR TreeFam; TF315188; -.
DR BioGRID-ORCS; 74580; 4 hits in 69 CRISPR screens.
DR PRO; PR:Q3U4I7; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q3U4I7; protein.
DR Bgee; ENSMUSG00000060224; Expressed in right kidney and 151 other tissues.
DR ExpressionAtlas; Q3U4I7; baseline and differential.
DR Genevisible; Q3U4I7; MM.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 1: Evidence at protein level;
KW FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Reference proteome.
FT CHAIN 1..581
FT /note="Pyridine nucleotide-disulfide oxidoreductase domain-
FT containing protein 2"
FT /id="PRO_0000244072"
FT BINDING 38..71
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255"
FT CONFLICT 19
FT /note="T -> A (in Ref. 1; BAE32444)"
FT /evidence="ECO:0000305"
FT CONFLICT 73
FT /note="A -> R (in Ref. 1; BAB29495)"
FT /evidence="ECO:0000305"
FT CONFLICT 106..115
FT /note="KHGLKLHLRD -> VDRLAWPGGW (in Ref. 1; BAC29991)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 581 AA; 62940 MW; 8BC394516E5AB468 CRC64;
MAAGGRGLIR ALHSSPCPTW KRAQSGANGR LKPEYDAVVI GAGHNGLVAA AYLQRLGVNT
AVFERRHVIG GAAVTEEIIP GFKFSRASYL LSLLRPQICT DLELKKHGLK LHLRDPYSFT
PMLEEGTLNR LPRSLLLGTD MAANQKEISQ FSRKDAQAFP RYEEFMKRLV LAIDPLLDAA
PVDTTAFQHG SLLQRLRALS TLKPLLKAGR TLGAQLPQYY EVLTAPISKV LDQRFESEPL
KATLATDAVI GAMTSPHTPG SGYVLLHHVM GSLEGTQGAW SYVQGGMGAL SDAIASSAAT
RGASIFTEKT VAKVQVNSEG RAQGVTLQDG EEVRSRVVLS CASPQVTFLE LTPQEWLPGA
FVKRISQLDT QSPVTKINVA VDRLPNFQAA PNAPGDQPQG HHQCSIHLNC EDTLLLHQAF
EDAKGGLPSQ KPMIELCIPS SLDPTLAPPG CHVVSLFTQY TPYTLAGGKV WNEQEKNTYA
DKVFDCIEAY APGFKRSVLA RDILTPPDLE RIFRLPGGNI FHGAMSLDQL YFARPVPQHS
DYRCPVQGLY LCGSGAHPGG GVMGAAGRNA AHVVFRDLKN M
