ID   AAEA_SALTI              Reviewed;         310 AA.
AC   Q8XF83; Q7AM50;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeA {ECO:0000255|HAMAP-Rule:MF_01544};
DE            Short=pHBA efflux pump protein A {ECO:0000255|HAMAP-Rule:MF_01544};
GN   Name=aaeA {ECO:0000255|HAMAP-Rule:MF_01544};
GN   OrderedLocusNames=STY3546, t3280;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Forms an efflux pump with AaeB. {ECO:0000255|HAMAP-
CC       Rule:MF_01544}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01544}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01544}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01544}.
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DR   EMBL; AL513382; CAD07880.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70815.1; -; Genomic_DNA.
DR   RefSeq; NP_457741.1; NC_003198.1.
DR   RefSeq; WP_000855134.1; NZ_UCTX01000030.1.
DR   AlphaFoldDB; Q8XF83; -.
DR   STRING; 220341.16504427; -.
DR   EnsemblBacteria; AAO70815; AAO70815; t3280.
DR   KEGG; stt:t3280; -.
DR   KEGG; sty:STY3546; -.
DR   PATRIC; fig|220341.7.peg.3609; -.
DR   eggNOG; COG1566; Bacteria.
DR   HOGENOM; CLU_018816_15_2_6; -.
DR   OMA; EVEPTFN; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01544; AaeA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022871; PHBA_efflux_pump_AaeA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..310
FT                   /note="p-hydroxybenzoic acid efflux pump subunit AaeA"
FT                   /id="PRO_0000201855"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01544"
SQ   SEQUENCE   310 AA;  34545 MW;  C3AA0165F9E761FC CRC64;
     MKTLTRKLSR TAITLVLVIL AFIAIFRAWV YYTESPWTRD ARFSADVVAI APDVAGLITH
     VNVHDNQLVK KDQVLFTIDQ PRYQKALAEA EADVAYYQVL AQEKRQEAGR RNRLGVQAMS
     REEIDQANNV LQTVLHQLAK AQATRDLAKL DLERTVIRAP ADGWVTNLNV YAGEFITRGS
     TAVALVKKNS FYVQAYMEET KLEGVRPGYR AEITPLGSNR VLKGTVDSVA AGVTNASSTS
     DAKGMATIDS NLEWVRLAQR VPVRIRLDEQ QGNLWPAGTT ATVVITGKQD RDASQDSFFR
     KLAHRLREFG