ID   PYREL_HALVD             Reviewed;         210 AA.
AC   Q8NKQ2; D4GVS9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=PyrE-like protein {ECO:0000255|HAMAP-Rule:MF_01214};
GN   Name=pyrE1; OrderedLocusNames=HVO_1082;
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC   STRAIN=DS2 / WR 340;
RX   PubMed=12533452; DOI=10.1128/jb.185.3.772-778.2003;
RA   Bitan-Banin G., Ortenberg R., Mevarech M.;
RT   "Development of a gene knockout system for the halophilic archaeon
RT   Haloferax volcanii by use of the pyrE gene.";
RL   J. Bacteriol. 185:772-778(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
CC   -!- FUNCTION: May have some orotate phosphoribosyltransferase activity, but
CC       not enough to ensure growth in the absence of the physiological OPRT.
CC   -!- DISRUPTION PHENOTYPE: Does not require uracil for growth, is partially
CC       resistant to 5-FOA (5-fluoroorotic acid).
CC       {ECO:0000269|PubMed:12533452}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000255|HAMAP-Rule:MF_01214}.
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DR   EMBL; AJ492197; CAD37329.1; -; Genomic_DNA.
DR   EMBL; CP001956; ADE04339.1; -; Genomic_DNA.
DR   RefSeq; WP_004043856.1; NZ_AOHU01000092.1.
DR   AlphaFoldDB; Q8NKQ2; -.
DR   SMR; Q8NKQ2; -.
DR   STRING; 309800.C498_13344; -.
DR   EnsemblBacteria; ADE04339; ADE04339; HVO_1082.
DR   GeneID; 8926693; -.
DR   KEGG; hvo:HVO_1082; -.
DR   eggNOG; arCOG00028; Archaea.
DR   HOGENOM; CLU_111001_0_0_2; -.
DR   OMA; DIHVDWS; -.
DR   OrthoDB; 77963at2157; -.
DR   Proteomes; UP000008243; Chromosome.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_01214; PyrE_like; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR022854; PyrE-like.
DR   PANTHER; PTHR19278:SF41; PTHR19278:SF41; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase.
FT   CHAIN           1..210
FT                   /note="PyrE-like protein"
FT                   /id="PRO_0000298894"
FT   REGION          39..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   210 AA;  22299 MW;  D403D28E12E9BCF4 CRC64;
     MKNVDDLIAS AAELADRGLS KGEIADELNV SRETASWLVE RSGAATEPEP RAEPEGPDDI
     HVDWNAIGSG GKRLTYVGRA LADLLMETNG EADVTVGIEK AGVPLATSVS RELETTLGAY
     SPAKHQWDEG DLEDLGGGFS RNFSPVEGRD CFIVDDTVTS GTTLRETIDA IRSEGGEPLA
     CVVIVDKQGV EEIDGVPVHS LINVVRVGEQ