ID   PYREL_METJA             Reviewed;         211 AA.
AC   Q59040;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=PyrE-like protein;
GN   OrderedLocusNames=MJ1646;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99667.1; -; Genomic_DNA.
DR   PIR; D64505; D64505.
DR   AlphaFoldDB; Q59040; -.
DR   SMR; Q59040; -.
DR   STRING; 243232.MJ_1646; -.
DR   EnsemblBacteria; AAB99667; AAB99667; MJ_1646.
DR   KEGG; mja:MJ_1646; -.
DR   eggNOG; arCOG00028; Archaea.
DR   HOGENOM; CLU_111001_0_0_2; -.
DR   InParanoid; Q59040; -.
DR   OMA; DIHVDWS; -.
DR   PhylomeDB; Q59040; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0019856; P:pyrimidine nucleobase biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006222; P:UMP biosynthetic process; IBA:GO_Central.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_01214; PyrE_like; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR022854; PyrE-like.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   PANTHER; PTHR19278:SF41; PTHR19278:SF41; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   SUPFAM; SSF88659; SSF88659; 1.
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase.
FT   CHAIN           1..211
FT                   /note="PyrE-like protein"
FT                   /id="PRO_0000110810"
SQ   SEQUENCE   211 AA;  23306 MW;  61693F216CB2CEF1 CRC64;
     MREIMNKELL KKVIELKSNG LTIGEIAEEL NVSMETARYL VLNAEKLLKE EEKAIKLENV
     DIFIDWKNIG SSANRLKYIS SIIVDILKSR NIEFDTVVGV STSGVPIATL VASELGKELT
     IYIPKKHISE EGKKITGSIS QNFSAVNYKR AVIIDDVVTS GSTLKECIKQ LKEVCSPKLV
     VVLIDKSGLD EIEGVPLIPL IRIGAVNVEQ K