ID   ATP8_DANRE              Reviewed;          54 AA.
AC   Q9MIY6;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=ATP synthase protein 8;
DE   AltName: Full=A6L;
DE   AltName: Full=F-ATPase subunit 8;
GN   Name=mt-atp8; Synonyms=atp8, atpase8, mtatp8;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000312|Proteomes:UP000000437};
RX   PubMed=11691861; DOI=10.1101/gr.156801;
RA   Broughton R.E., Milam J.E., Roe B.A.;
RT   "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome
RT   and evolutionary patterns in vertebrate mitochondrial DNA.";
RL   Genome Res. 11:1958-1967(2001).
CC   -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC       Complex V) produces ATP from ADP in the presence of a proton gradient
CC       across the membrane which is generated by electron transport complexes
CC       of the respiratory chain. F-type ATPases consist of two structural
CC       domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC       - containing the membrane proton channel, linked together by a central
CC       stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC       catalytic domain of F(1) is coupled via a rotary mechanism of the
CC       central stalk subunits to proton translocation. Part of the complex
CC       F(0) domain. Minor subunit located with subunit a in the membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC       - and CF(0) - the membrane proton channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the ATPase protein 8 family. {ECO:0000305}.
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DR   EMBL; AC024175; AAF74301.1; -; Genomic_DNA.
DR   RefSeq; NP_059335.1; NC_002333.2.
DR   AlphaFoldDB; Q9MIY6; -.
DR   SMR; Q9MIY6; -.
DR   STRING; 7955.ENSDARP00000087873; -.
DR   PaxDb; Q9MIY6; -.
DR   Ensembl; ENSDART00000093611; ENSDARP00000087873; ENSDARG00000063910.
DR   GeneID; 140520; -.
DR   KEGG; dre:140520; -.
DR   CTD; 4509; -.
DR   ZFIN; ZDB-GENE-011205-19; mt-atp8.
DR   eggNOG; ENOG502SGKX; Eukaryota.
DR   GeneTree; ENSGT00970000198192; -.
DR   HOGENOM; CLU_212888_0_0_1; -.
DR   InParanoid; Q9MIY6; -.
DR   OMA; MPQLNPN; -.
DR   OrthoDB; 1621322at2759; -.
DR   PhylomeDB; Q9MIY6; -.
DR   PRO; PR:Q9MIY6; -.
DR   Proteomes; UP000000437; Mitochondrion MT.
DR   Proteomes; UP000814640; Mitochondrion.
DR   Bgee; ENSDARG00000063910; Expressed in blastula and 39 other tissues.
DR   ExpressionAtlas; Q9MIY6; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR   InterPro; IPR001421; ATP8_metazoa.
DR   Pfam; PF00895; ATP-synt_8; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW   Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..54
FT                   /note="ATP synthase protein 8"
FT                   /id="PRO_0000195498"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          35..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   54 AA;  6589 MW;  7B1C0F0B1F0A12C0 CRC64;
     MPQLNPKPWF MILFFSWVIF LTIIPTKIIN HIQPNDPTQV DAKEHKNDTW NWPW