ATP8_DROME
ID ATP8_DROME Reviewed; 53 AA.
AC P84345; B2L9S1; B6E0P5; P03932;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=ATP synthase protein 8;
DE AltName: Full=A6L;
DE AltName: Full=F-ATPase subunit 8;
GN Name=mt:ATPase8; Synonyms=ATP8, ATPase8, Mtatp8;
OS Drosophila melanogaster (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6408489; DOI=10.1038/304234a0;
RA de Bruijn M.H.L.;
RT "Drosophila melanogaster mitochondrial DNA, a novel organization and
RT genetic code.";
RL Nature 304:234-241(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oregon-R, and Zimbabwe 53;
RX PubMed=10903372; DOI=10.1007/s002390010066;
RA Ballard J.W.O.;
RT "Comparative genomics of mitochondrial DNA in members of the Drosophila
RT melanogaster subgroup.";
RL J. Mol. Evol. 51:48-63(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Paris;
RX PubMed=11298822; DOI=10.1046/j.1365-2540.2001.00814.x;
RA Azou Y., Bregliano J.C.;
RT "I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of
RT the mitochondrial DNA in reactive strains exhibiting different potentials
RT for I factor transposition.";
RL Heredity 86:110-116(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Alstonvl, Brownsvl, Dahomey, Japan, Mysore, and W1118iso;
RX PubMed=18727704; DOI=10.1111/j.1474-9726.2008.00428.x;
RA Clancy D.J.;
RT "Variation in mitochondrial genotype has substantial lifespan effects which
RT may be modulated by nuclear background.";
RL Aging Cell 7:795-804(2008).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=18296276; DOI=10.1098/rsbl.2007.0575;
RA O'Grady P.M., DeSalle R.;
RT "Out of Hawaii: the origin and biogeography of the genus Scaptomyza
RT (Diptera: Drosophilidae).";
RL Biol. Lett. 4:195-199(2008).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8825764; DOI=10.1111/j.1365-2583.1995.tb00032.x;
RA Lewis D.L., Farr C.L., Kaguni L.S.;
RT "Drosophila melanogaster mitochondrial DNA: completion of the nucleotide
RT sequence and evolutionary comparisons.";
RL Insect Mol. Biol. 4:263-278(1995).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RA Wan K., Celniker S.;
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Part of the complex
CC F(0) domain. Minor subunit located with subunit a in the membrane (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the ATPase protein 8 family. {ECO:0000305}.
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DR EMBL; J01404; AAB59241.1; -; Genomic_DNA.
DR EMBL; AF200828; AAF77229.1; -; Genomic_DNA.
DR EMBL; AF200829; AAF77241.1; -; Genomic_DNA.
DR EMBL; AJ400907; CAB91054.1; -; Genomic_DNA.
DR EMBL; FJ190105; ACI28545.1; -; Genomic_DNA.
DR EMBL; FJ190106; ACI28558.1; -; Genomic_DNA.
DR EMBL; FJ190107; ACI28571.1; -; Genomic_DNA.
DR EMBL; FJ190108; ACI28584.1; -; Genomic_DNA.
DR EMBL; FJ190109; ACI28597.1; -; Genomic_DNA.
DR EMBL; FJ190110; ACI28610.1; -; Genomic_DNA.
DR EMBL; EU493757; ACC94833.1; -; Genomic_DNA.
DR EMBL; U37541; AAC47814.1; -; Genomic_DNA.
DR EMBL; KJ947872; AIC64007.1; -; Genomic_DNA.
DR PIR; A01066; PWFF8.
DR RefSeq; YP_009047269.1; NC_024511.2.
DR AlphaFoldDB; P84345; -.
DR SMR; P84345; -.
DR BioGRID; 2595067; 1.
DR STRING; 7227.FBpp0100178; -.
DR PaxDb; P84345; -.
DR EnsemblMetazoa; FBtr0100866; FBpp0100178; FBgn0013673.
DR GeneID; 19893538; -.
DR KEGG; dme:Dmel_CG34072; -.
DR CTD; 4509; -.
DR FlyBase; FBgn0013673; mt:ATPase8.
DR VEuPathDB; VectorBase:FBgn0013673; -.
DR eggNOG; ENOG502T7W7; Eukaryota.
DR HOGENOM; CLU_3070490_0_0_1; -.
DR InParanoid; P84345; -.
DR BioGRID-ORCS; 19893538; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 19893538; -.
DR PRO; PR:P84345; -.
DR Proteomes; UP000000803; Mitochondrion.
DR Bgee; FBgn0013673; Expressed in Malpighian tubule and 11 other tissues.
DR ExpressionAtlas; P84345; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR InterPro; IPR001421; ATP8_metazoa.
DR Pfam; PF00895; ATP-synt_8; 1.
PE 3: Inferred from homology;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..53
FT /note="ATP synthase protein 8"
FT /id="PRO_0000195523"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 53 AA; 6365 MW; 45D2C68AA437FC23 CRC64;
MPQMAPISWL LLFIIFSITF ILFCSINYYS YMPNSPKSNE LKNINLNSMN WKW
