ATP8_DROSI
ID ATP8_DROSI Reviewed; 53 AA.
AC P50270; Q94PM8; Q9ME70;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 3.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=ATP synthase protein 8;
DE AltName: Full=A6L;
DE AltName: Full=F-ATPase subunit 8;
GN Name=mt:ATPase8; Synonyms=ATP8, ATPase8, Mtatp8;
OS Drosophila simulans (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8365657; DOI=10.1017/s0016672300031360;
RA Kaneko M., Satta Y., Matsuura E.T., Chigusa S.I.;
RT "Evolution of the mitochondrial ATPase 6 gene in Drosophila: unusually high
RT level of polymorphism in D. melanogaster.";
RL Genet. Res. 61:195-204(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AU023, KY007, KY045, KY201, and KY215;
RX PubMed=14660690; DOI=10.1093/molbev/msh028;
RA Ballard J.W.O.;
RT "Sequential evolution of a symbiont inferred from the host: Wolbachia and
RT Drosophila simulans.";
RL Mol. Biol. Evol. 21:428-442(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C167, DSR, DSW, HW00, HW09, MD106, MD111, MD112, MD199, MD221,
RC MD225, MDW86, NC37, NC48, RU00, RU01, RU07, RU259, RU35, SC00, TT00, and
RC TT01;
RX PubMed=10903373; DOI=10.1007/s002390010067;
RA Ballard J.W.;
RT "Comparative genomics of mitochondrial DNA in Drosophila simulans.";
RL J. Mol. Evol. 51:64-75(2000).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Part of the complex
CC F(0) domain. Minor subunit located with subunit a in the membrane (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the ATPase protein 8 family. {ECO:0000305}.
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DR EMBL; S64977; AAD13957.1; -; Genomic_DNA.
DR EMBL; AF200833; AAF77292.1; -; Genomic_DNA.
DR EMBL; AF200834; AAF77306.1; -; Genomic_DNA.
DR EMBL; AF200835; AAF77319.1; -; Genomic_DNA.
DR EMBL; AF200836; AAF77332.1; -; Genomic_DNA.
DR EMBL; AF200837; AAF77345.1; -; Genomic_DNA.
DR EMBL; AF200838; AAF77358.1; -; Genomic_DNA.
DR EMBL; AF200839; AAF77372.1; -; Genomic_DNA.
DR EMBL; AF200840; AAF77384.1; -; Genomic_DNA.
DR EMBL; AF200841; AAF77397.1; -; Genomic_DNA.
DR EMBL; AF200842; AAF77409.1; -; Genomic_DNA.
DR EMBL; AF200843; AAF77423.1; -; Genomic_DNA.
DR EMBL; AF200844; AAF77436.1; -; Genomic_DNA.
DR EMBL; AF200845; AAF77449.1; -; Genomic_DNA.
DR EMBL; AF200846; AAF77462.1; -; Genomic_DNA.
DR EMBL; AF200847; AAF77475.1; -; Genomic_DNA.
DR EMBL; AF200848; AAF77488.1; -; Genomic_DNA.
DR EMBL; AF200849; AAF77502.1; -; Genomic_DNA.
DR EMBL; AF200850; AAF77514.1; -; Genomic_DNA.
DR EMBL; AF200851; AAF77528.1; -; Genomic_DNA.
DR EMBL; AF200852; AAF77540.1; -; Genomic_DNA.
DR EMBL; AF200853; AAF77553.1; -; Genomic_DNA.
DR EMBL; AF200854; AAF77566.1; -; Genomic_DNA.
DR EMBL; AY518670; AAR91388.1; -; Genomic_DNA.
DR EMBL; AY518671; AAR91404.1; -; Genomic_DNA.
DR EMBL; AY518672; AAR91417.1; -; Genomic_DNA.
DR EMBL; AY518673; AAR91430.1; -; Genomic_DNA.
DR EMBL; AY518674; AAR91443.1; -; Genomic_DNA.
DR RefSeq; NP_982325.1; NC_005781.1.
DR AlphaFoldDB; P50270; -.
DR SMR; P50270; -.
DR STRING; 7240.P50270; -.
DR PRIDE; P50270; -.
DR GeneID; 2760958; -.
DR KEGG; dsi:ATP8; -.
DR CTD; 4509; -.
DR Proteomes; UP000000304; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR InterPro; IPR001421; ATP8_metazoa.
DR Pfam; PF00895; ATP-synt_8; 1.
PE 3: Inferred from homology;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..53
FT /note="ATP synthase protein 8"
FT /id="PRO_0000195525"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 26
FT /note="I -> M (in strain: HW00, HW09, NC37, NC48, TT00 and
FT TT01)"
FT VARIANT 32
FT /note="M -> I (in strain: HW00, HW09, NC37, NC48, TT00 and
FT TT01)"
FT VARIANT 34
FT /note="N -> D (in strain: AU023, C167, DSR, DSW, KY007,
FT KY201, KY215, MD106, MD225, RU35 and SC00)"
SQ SEQUENCE 53 AA; 6365 MW; 45D2C68AA437FC23 CRC64;
MPQMAPISWL LLFIIFSITF ILFCSINYYS YMPNSPKSNE LKNINLNSMN WKW
