ATP8_HUMAN
ID ATP8_HUMAN Reviewed; 68 AA.
AC P03928; Q34771;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 193.
DE RecName: Full=ATP synthase protein 8;
DE AltName: Full=A6L;
DE AltName: Full=F-ATPase subunit 8;
GN Name=MT-ATP8; Synonyms=ATP8, ATPASE8, MTATP8;
OS Homo sapiens (Human).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=7219534; DOI=10.1038/290457a0;
RA Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R.,
RA Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H.,
RA Smith A.J.H., Staden R., Young I.G.;
RT "Sequence and organization of the human mitochondrial genome.";
RL Nature 290:457-465(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Placenta;
RX PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT "Recent African origin of modern humans revealed by complete sequences of
RT hominoid mitochondrial DNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12949126; DOI=10.1093/molbev/msg230;
RA Moilanen J.S., Finnila S., Majamaa K.;
RT "Lineage-specific selection in human mtDNA: lack of polymorphisms in a
RT segment of MTND5 gene in haplogroup J.";
RL Mol. Biol. Evol. 20:2132-2142(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11130070; DOI=10.1038/35047064;
RA Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
RT "Mitochondrial genome variation and the origin of modern humans.";
RL Nature 408:708-713(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12840039; DOI=10.1101/gr.686603;
RA Ingman M., Gyllensten U.;
RT "Mitochondrial genome variation and evolutionary history of Australian and
RT New Guinean aborigines.";
RL Genome Res. 13:1600-1606(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14760490; DOI=10.1007/s00414-004-0427-6;
RA Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T.,
RA Irwin J.A., Parsons T.J.;
RT "Single nucleotide polymorphisms over the entire mtDNA genome that increase
RT the power of forensic testing in Caucasians.";
RL Int. J. Legal Med. 118:137-146(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [9]
RP INTERACTION WITH PRICKLE3.
RX PubMed=32516135; DOI=10.1172/jci134965;
RA Yu J., Liang X., Ji Y., Ai C., Liu J., Zhu L., Nie Z., Jin X., Wang C.,
RA Zhang J., Zhao F., Mei S., Zhao X., Zhou X., Zhang M., Wang M., Huang T.,
RA Jiang P., Guan M.X.;
RT "PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic
RT neuropathy.";
RL J. Clin. Invest. 130:4935-4946(2020).
RN [10]
RP VARIANTS PRO-17 AND SER-21.
RX PubMed=1757091; DOI=10.1007/bf00206061;
RA Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R.,
RA Utthanaphol P., Byrne E.;
RT "Normal variants of human mitochondrial DNA and translation products: the
RT building of a reference data base.";
RL Hum. Genet. 88:139-145(1991).
RN [11]
RP VARIANT THR-28.
RX PubMed=9461455; DOI=10.1093/nar/26.4.967;
RA Rieder M.J., Taylor S.L., Tobe V.O., Nickerson D.A.;
RT "Automating the identification of DNA variations using quality-based
RT fluorescence re-sequencing: analysis of the human mitochondrial genome.";
RL Nucleic Acids Res. 26:967-973(1998).
RN [12]
RP VARIANT MC5DM2 ARG-55, INVOLVEMENT IN CMHI, AND VARIANT CMHI ARG-55.
RX PubMed=19188198; DOI=10.1136/jmg.2008.063149;
RA Ware S.M., El-Hassan N., Kahler S.G., Zhang Q., Ma Y.W., Miller E.,
RA Wong B., Spicer R.L., Craigen W.J., Kozel B.A., Grange D.K., Wong L.J.;
RT "Infantile cardiomyopathy caused by a mutation in the overlapping region of
RT mitochondrial ATPase 6 and 8 genes.";
RL J. Med. Genet. 46:308-314(2009).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Part of the complex
CC F(0) domain. Minor subunit located with subunit a in the membrane (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. Component of an ATP synthase
CC complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF,
CC ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO,
CC ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3
CC (PubMed:32516135). {ECO:0000250, ECO:0000269|PubMed:32516135}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC protein.
CC -!- DISEASE: Mitochondrial complex V deficiency, mitochondrial 2 (MC5DM2)
CC [MIM:516070]: A mitochondrial disorder with heterogeneous clinical
CC manifestations including neuropathy, ataxia, hypertrophic
CC cardiomyopathy. Hypertrophic cardiomyopathy can present with negligible
CC to extreme hypertrophy, minimal to extensive fibrosis and myocyte
CC disarray, absent to severe left ventricular outflow tract obstruction,
CC and distinct septal contours/morphologies with extremely varying
CC clinical course. {ECO:0000269|PubMed:19188198}. Note=The disease is
CC caused by variants affecting the gene represented in this entry.
CC -!- DISEASE: Cardiomyopathy, infantile hypertrophic (CMHI) [MIM:500006]: An
CC infantile form of hypertrophic cardiomyopathy, a heart disorder
CC characterized by ventricular hypertrophy, which is usually asymmetric
CC and often involves the interventricular septum. The symptoms include
CC dyspnea, syncope, collapse, palpitations, and chest pain. They can be
CC readily provoked by exercise. The disorder has inter- and intrafamilial
CC variability ranging from benign to malignant forms with high risk of
CC cardiac failure and sudden cardiac death.
CC {ECO:0000269|PubMed:19188198}. Note=The disease is caused by variants
CC affecting distinct genetic loci, including the gene represented in this
CC entry.
CC -!- SIMILARITY: Belongs to the ATPase protein 8 family. {ECO:0000305}.
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DR EMBL; J01415; AAB58947.1; -; Genomic_DNA.
DR EMBL; V00662; CAA24030.1; -; Genomic_DNA.
DR EMBL; D38112; BAA07294.1; -; Genomic_DNA.
DR EMBL; AY339402; AAP89040.1; -; Genomic_DNA.
DR EMBL; AY339403; AAP89053.1; -; Genomic_DNA.
DR EMBL; AY339404; AAP89066.1; -; Genomic_DNA.
DR EMBL; AY339405; AAP89079.1; -; Genomic_DNA.
DR EMBL; AY339406; AAP89092.1; -; Genomic_DNA.
DR EMBL; AY339407; AAP89105.1; -; Genomic_DNA.
DR EMBL; AY339408; AAP89118.1; -; Genomic_DNA.
DR EMBL; AY339409; AAP89131.1; -; Genomic_DNA.
DR EMBL; AY339410; AAP89144.1; -; Genomic_DNA.
DR EMBL; AY339411; AAP89157.1; -; Genomic_DNA.
DR EMBL; AY339412; AAP89170.1; -; Genomic_DNA.
DR EMBL; AY339413; AAP89183.1; -; Genomic_DNA.
DR EMBL; AY339414; AAP89196.1; -; Genomic_DNA.
DR EMBL; AY339415; AAP89209.1; -; Genomic_DNA.
DR EMBL; AY339416; AAP89222.1; -; Genomic_DNA.
DR EMBL; AY339417; AAP89235.1; -; Genomic_DNA.
DR EMBL; AY339418; AAP89248.1; -; Genomic_DNA.
DR EMBL; AY339419; AAP89261.1; -; Genomic_DNA.
DR EMBL; AY339420; AAP89274.1; -; Genomic_DNA.
DR EMBL; AY339421; AAP89287.1; -; Genomic_DNA.
DR EMBL; AY339422; AAP89300.1; -; Genomic_DNA.
DR EMBL; AY339423; AAP89313.1; -; Genomic_DNA.
DR EMBL; AY339424; AAP89326.1; -; Genomic_DNA.
DR EMBL; AY339425; AAP89339.1; -; Genomic_DNA.
DR EMBL; AY339426; AAP89352.1; -; Genomic_DNA.
DR EMBL; AY339427; AAP89365.1; -; Genomic_DNA.
DR EMBL; AY339428; AAP89378.1; -; Genomic_DNA.
DR EMBL; AY339429; AAP89391.1; -; Genomic_DNA.
DR EMBL; AY339430; AAP89404.1; -; Genomic_DNA.
DR EMBL; AY339431; AAP89417.1; -; Genomic_DNA.
DR EMBL; AY339432; AAP89430.1; -; Genomic_DNA.
DR EMBL; AY339433; AAP89443.1; -; Genomic_DNA.
DR EMBL; AY339434; AAP89456.1; -; Genomic_DNA.
DR EMBL; AY339435; AAP89469.1; -; Genomic_DNA.
DR EMBL; AY339436; AAP89482.1; -; Genomic_DNA.
DR EMBL; AY339437; AAP89495.1; -; Genomic_DNA.
DR EMBL; AY339438; AAP89508.1; -; Genomic_DNA.
DR EMBL; AY339439; AAP89521.1; -; Genomic_DNA.
DR EMBL; AY339440; AAP89534.1; -; Genomic_DNA.
DR EMBL; AY339441; AAP89547.1; -; Genomic_DNA.
DR EMBL; AY339442; AAP89560.1; -; Genomic_DNA.
DR EMBL; AY339443; AAP89573.1; -; Genomic_DNA.
DR EMBL; AY339444; AAP89586.1; -; Genomic_DNA.
DR EMBL; AY339445; AAP89599.1; -; Genomic_DNA.
DR EMBL; AY339446; AAP89612.1; -; Genomic_DNA.
DR EMBL; AY339447; AAP89625.1; -; Genomic_DNA.
DR EMBL; AY339448; AAP89638.1; -; Genomic_DNA.
DR EMBL; AY339449; AAP89651.1; -; Genomic_DNA.
DR EMBL; AY339450; AAP89664.1; -; Genomic_DNA.
DR EMBL; AY339451; AAP89677.1; -; Genomic_DNA.
DR EMBL; AY339452; AAP89690.1; -; Genomic_DNA.
DR EMBL; AY339453; AAP89703.1; -; Genomic_DNA.
DR EMBL; AY339454; AAP89716.1; -; Genomic_DNA.
DR EMBL; AY339455; AAP89729.1; -; Genomic_DNA.
DR EMBL; AY339456; AAP89742.1; -; Genomic_DNA.
DR EMBL; AY339457; AAP89755.1; -; Genomic_DNA.
DR EMBL; AY339458; AAP89768.1; -; Genomic_DNA.
DR EMBL; AY339459; AAP89781.1; -; Genomic_DNA.
DR EMBL; AY339460; AAP89794.1; -; Genomic_DNA.
DR EMBL; AY339461; AAP89807.1; -; Genomic_DNA.
DR EMBL; AY339462; AAP89820.1; -; Genomic_DNA.
DR EMBL; AY339463; AAP89833.1; -; Genomic_DNA.
DR EMBL; AY339464; AAP89846.1; -; Genomic_DNA.
DR EMBL; AY339465; AAP89859.1; -; Genomic_DNA.
DR EMBL; AY339466; AAP89872.1; -; Genomic_DNA.
DR EMBL; AY339467; AAP89885.1; -; Genomic_DNA.
DR EMBL; AY339468; AAP89898.1; -; Genomic_DNA.
DR EMBL; AY339469; AAP89911.1; -; Genomic_DNA.
DR EMBL; AY339470; AAP89924.1; -; Genomic_DNA.
DR EMBL; AY339471; AAP89937.1; -; Genomic_DNA.
DR EMBL; AY339472; AAP89950.1; -; Genomic_DNA.
DR EMBL; AY339473; AAP89963.1; -; Genomic_DNA.
DR EMBL; AY339474; AAP89976.1; -; Genomic_DNA.
DR EMBL; AY339475; AAP89989.1; -; Genomic_DNA.
DR EMBL; AY339476; AAP90002.1; -; Genomic_DNA.
DR EMBL; AY339477; AAP90015.1; -; Genomic_DNA.
DR EMBL; AY339478; AAP90028.1; -; Genomic_DNA.
DR EMBL; AY339479; AAP90041.1; -; Genomic_DNA.
DR EMBL; AY339480; AAP90054.1; -; Genomic_DNA.
DR EMBL; AY339481; AAP90067.1; -; Genomic_DNA.
DR EMBL; AY339482; AAP90080.1; -; Genomic_DNA.
DR EMBL; AY339483; AAP90093.1; -; Genomic_DNA.
DR EMBL; AY339484; AAP90106.1; -; Genomic_DNA.
DR EMBL; AY339485; AAP90119.1; -; Genomic_DNA.
DR EMBL; AY339486; AAP90132.1; -; Genomic_DNA.
DR EMBL; AY339487; AAP90145.1; -; Genomic_DNA.
DR EMBL; AY339488; AAP90158.1; -; Genomic_DNA.
DR EMBL; AY339489; AAP90171.1; -; Genomic_DNA.
DR EMBL; AY339490; AAP90184.1; -; Genomic_DNA.
DR EMBL; AY339491; AAP90197.1; -; Genomic_DNA.
DR EMBL; AY339492; AAP90210.1; -; Genomic_DNA.
DR EMBL; AY339493; AAP90223.1; -; Genomic_DNA.
DR EMBL; AY339494; AAP90236.1; -; Genomic_DNA.
DR EMBL; AY339495; AAP90249.1; -; Genomic_DNA.
DR EMBL; AY339496; AAP90262.1; -; Genomic_DNA.
DR EMBL; AY339497; AAP90275.1; -; Genomic_DNA.
DR EMBL; AY339498; AAP90288.1; -; Genomic_DNA.
DR EMBL; AY339499; AAP90301.1; -; Genomic_DNA.
DR EMBL; AY339500; AAP90314.1; -; Genomic_DNA.
DR EMBL; AY339501; AAP90327.1; -; Genomic_DNA.
DR EMBL; AY339502; AAP90340.1; -; Genomic_DNA.
DR EMBL; AY339503; AAP90353.1; -; Genomic_DNA.
DR EMBL; AY339504; AAP90366.1; -; Genomic_DNA.
DR EMBL; AY339505; AAP90379.1; -; Genomic_DNA.
DR EMBL; AY339506; AAP90392.1; -; Genomic_DNA.
DR EMBL; AY339507; AAP90405.1; -; Genomic_DNA.
DR EMBL; AY339508; AAP90418.1; -; Genomic_DNA.
DR EMBL; AY339509; AAP90431.1; -; Genomic_DNA.
DR EMBL; AY339510; AAP90444.1; -; Genomic_DNA.
DR EMBL; AY339511; AAP90457.1; -; Genomic_DNA.
DR EMBL; AY339512; AAP90470.1; -; Genomic_DNA.
DR EMBL; AY339513; AAP90483.2; -; Genomic_DNA.
DR EMBL; AY339515; AAP90509.1; -; Genomic_DNA.
DR EMBL; AY339516; AAP90522.1; -; Genomic_DNA.
DR EMBL; AY339517; AAP90535.1; -; Genomic_DNA.
DR EMBL; AY339518; AAP90548.1; -; Genomic_DNA.
DR EMBL; AY339519; AAP90561.1; -; Genomic_DNA.
DR EMBL; AY339520; AAP90574.1; -; Genomic_DNA.
DR EMBL; AY339521; AAP90587.1; -; Genomic_DNA.
DR EMBL; AY339522; AAP90600.1; -; Genomic_DNA.
DR EMBL; AY339523; AAP90613.1; -; Genomic_DNA.
DR EMBL; AY339524; AAP90626.1; -; Genomic_DNA.
DR EMBL; AY339525; AAP90639.1; -; Genomic_DNA.
DR EMBL; AY339526; AAP90652.1; -; Genomic_DNA.
DR EMBL; AY339527; AAP90665.1; -; Genomic_DNA.
DR EMBL; AY339528; AAP90678.1; -; Genomic_DNA.
DR EMBL; AY339529; AAP90691.1; -; Genomic_DNA.
DR EMBL; AY339530; AAP90704.1; -; Genomic_DNA.
DR EMBL; AY339531; AAP90717.1; -; Genomic_DNA.
DR EMBL; AY339532; AAP90730.1; -; Genomic_DNA.
DR EMBL; AY339533; AAP90743.1; -; Genomic_DNA.
DR EMBL; AY339534; AAP90756.1; -; Genomic_DNA.
DR EMBL; AY339535; AAP90769.1; -; Genomic_DNA.
DR EMBL; AY339536; AAP90782.1; -; Genomic_DNA.
DR EMBL; AY339537; AAP90795.1; -; Genomic_DNA.
DR EMBL; AY339538; AAP90808.1; -; Genomic_DNA.
DR EMBL; AY339539; AAP90821.1; -; Genomic_DNA.
DR EMBL; AY339540; AAP90834.1; -; Genomic_DNA.
DR EMBL; AY339541; AAP90847.1; -; Genomic_DNA.
DR EMBL; AY339542; AAP90860.1; -; Genomic_DNA.
DR EMBL; AY339543; AAP90873.1; -; Genomic_DNA.
DR EMBL; AY339544; AAP90886.1; -; Genomic_DNA.
DR EMBL; AY339545; AAP90899.1; -; Genomic_DNA.
DR EMBL; AY339546; AAP90912.1; -; Genomic_DNA.
DR EMBL; AY339547; AAP90925.1; -; Genomic_DNA.
DR EMBL; AY339548; AAP90938.1; -; Genomic_DNA.
DR EMBL; AY339549; AAP90951.1; -; Genomic_DNA.
DR EMBL; AY339550; AAP90964.1; -; Genomic_DNA.
DR EMBL; AY339551; AAP90977.1; -; Genomic_DNA.
DR EMBL; AY339552; AAP90990.1; -; Genomic_DNA.
DR EMBL; AY339553; AAP91003.1; -; Genomic_DNA.
DR EMBL; AY339554; AAP91016.1; -; Genomic_DNA.
DR EMBL; AY339555; AAP91029.1; -; Genomic_DNA.
DR EMBL; AY339556; AAP91042.1; -; Genomic_DNA.
DR EMBL; AY339557; AAP91055.1; -; Genomic_DNA.
DR EMBL; AY339558; AAP91068.1; -; Genomic_DNA.
DR EMBL; AY339559; AAP91081.1; -; Genomic_DNA.
DR EMBL; AY339560; AAP91094.1; -; Genomic_DNA.
DR EMBL; AY339561; AAP91107.1; -; Genomic_DNA.
DR EMBL; AY339562; AAP91120.1; -; Genomic_DNA.
DR EMBL; AY339563; AAP91133.1; -; Genomic_DNA.
DR EMBL; AY339564; AAP91146.1; -; Genomic_DNA.
DR EMBL; AY339565; AAP91159.1; -; Genomic_DNA.
DR EMBL; AY339566; AAP91172.1; -; Genomic_DNA.
DR EMBL; AY339567; AAP91185.1; -; Genomic_DNA.
DR EMBL; AY339568; AAP91198.1; -; Genomic_DNA.
DR EMBL; AY339569; AAP91211.1; -; Genomic_DNA.
DR EMBL; AY339570; AAP91224.1; -; Genomic_DNA.
DR EMBL; AY339571; AAP91237.1; -; Genomic_DNA.
DR EMBL; AY339572; AAP91250.1; -; Genomic_DNA.
DR EMBL; AY339573; AAP91263.1; -; Genomic_DNA.
DR EMBL; AY339574; AAP91276.1; -; Genomic_DNA.
DR EMBL; AY339575; AAP91289.1; -; Genomic_DNA.
DR EMBL; AY339576; AAP91302.1; -; Genomic_DNA.
DR EMBL; AY339577; AAP91315.1; -; Genomic_DNA.
DR EMBL; AY339578; AAP91328.1; -; Genomic_DNA.
DR EMBL; AY339579; AAP91341.1; -; Genomic_DNA.
DR EMBL; AY339580; AAP91354.1; -; Genomic_DNA.
DR EMBL; AY339581; AAP91367.1; -; Genomic_DNA.
DR EMBL; AY339582; AAP91380.1; -; Genomic_DNA.
DR EMBL; AY339583; AAP91393.1; -; Genomic_DNA.
DR EMBL; AY339584; AAP91406.1; -; Genomic_DNA.
DR EMBL; AY339585; AAP91419.1; -; Genomic_DNA.
DR EMBL; AY339586; AAP91432.1; -; Genomic_DNA.
DR EMBL; AY339587; AAP91445.1; -; Genomic_DNA.
DR EMBL; AY339588; AAP91458.1; -; Genomic_DNA.
DR EMBL; AY339589; AAP91471.1; -; Genomic_DNA.
DR EMBL; AY339590; AAP91484.1; -; Genomic_DNA.
DR EMBL; AY339591; AAP91497.1; -; Genomic_DNA.
DR EMBL; AY339592; AAP91510.1; -; Genomic_DNA.
DR EMBL; AY339593; AAP91523.1; -; Genomic_DNA.
DR EMBL; AF346963; AAK17211.1; -; Genomic_DNA.
DR EMBL; AF346964; AAK17224.1; -; Genomic_DNA.
DR EMBL; AF346965; AAK17237.1; -; Genomic_DNA.
DR EMBL; AF346966; AAK17250.1; -; Genomic_DNA.
DR EMBL; AF346967; AAK17263.1; -; Genomic_DNA.
DR EMBL; AF346968; AAK17276.1; -; Genomic_DNA.
DR EMBL; AF346969; AAK17289.1; -; Genomic_DNA.
DR EMBL; AF346970; AAK17302.1; -; Genomic_DNA.
DR EMBL; AF346971; AAK17315.1; -; Genomic_DNA.
DR EMBL; AF346972; AAK17328.1; -; Genomic_DNA.
DR EMBL; AF346973; AAK17341.1; -; Genomic_DNA.
DR EMBL; AF346974; AAK17354.1; -; Genomic_DNA.
DR EMBL; AF346975; AAK17367.1; -; Genomic_DNA.
DR EMBL; AF346976; AAK17380.1; -; Genomic_DNA.
DR EMBL; AF346977; AAK17393.1; -; Genomic_DNA.
DR EMBL; AF346978; AAK17406.1; -; Genomic_DNA.
DR EMBL; AF346979; AAK17419.1; -; Genomic_DNA.
DR EMBL; AF346980; AAK17432.1; -; Genomic_DNA.
DR EMBL; AF346981; AAK17445.1; -; Genomic_DNA.
DR EMBL; AF346982; AAK17458.1; -; Genomic_DNA.
DR EMBL; AF346983; AAK17471.1; -; Genomic_DNA.
DR EMBL; AF346985; AAK17497.1; -; Genomic_DNA.
DR EMBL; AF346986; AAK17510.1; -; Genomic_DNA.
DR EMBL; AF346987; AAK17523.1; -; Genomic_DNA.
DR EMBL; AF346988; AAK17536.1; -; Genomic_DNA.
DR EMBL; AF346991; AAK17575.1; -; Genomic_DNA.
DR EMBL; AF346992; AAK17588.1; -; Genomic_DNA.
DR EMBL; AF346993; AAK17601.1; -; Genomic_DNA.
DR EMBL; AF346994; AAK17614.1; -; Genomic_DNA.
DR EMBL; AF346995; AAK17627.1; -; Genomic_DNA.
DR EMBL; AF346996; AAK17640.1; -; Genomic_DNA.
DR EMBL; AF346997; AAK17653.1; -; Genomic_DNA.
DR EMBL; AF347000; AAK17692.1; -; Genomic_DNA.
DR EMBL; AF347001; AAK17705.1; -; Genomic_DNA.
DR EMBL; AF347002; AAK17718.1; -; Genomic_DNA.
DR EMBL; AF347003; AAK17731.1; -; Genomic_DNA.
DR EMBL; AF347004; AAK17744.1; -; Genomic_DNA.
DR EMBL; AF347005; AAK17757.1; -; Genomic_DNA.
DR EMBL; AF347006; AAK17770.1; -; Genomic_DNA.
DR EMBL; AF347007; AAK17783.1; -; Genomic_DNA.
DR EMBL; AF347008; AAK17796.1; -; Genomic_DNA.
DR EMBL; AF347009; AAK17809.1; -; Genomic_DNA.
DR EMBL; AF347011; AAK17835.1; -; Genomic_DNA.
DR EMBL; AF347012; AAK17848.1; -; Genomic_DNA.
DR EMBL; AF347013; AAK17861.1; -; Genomic_DNA.
DR EMBL; AF347014; AAK17874.1; -; Genomic_DNA.
DR EMBL; AF347015; AAK17887.1; -; Genomic_DNA.
DR EMBL; AY289051; AAP47884.1; -; Genomic_DNA.
DR EMBL; AY289052; AAP47897.1; -; Genomic_DNA.
DR EMBL; AY289053; AAP47910.1; -; Genomic_DNA.
DR EMBL; AY289056; AAP47949.1; -; Genomic_DNA.
DR EMBL; AY289057; AAP47962.1; -; Genomic_DNA.
DR EMBL; AY289058; AAP47975.1; -; Genomic_DNA.
DR EMBL; AY289059; AAP47988.1; -; Genomic_DNA.
DR EMBL; AY289060; AAP48001.1; -; Genomic_DNA.
DR EMBL; AY289061; AAP48014.1; -; Genomic_DNA.
DR EMBL; AY289062; AAP48027.1; -; Genomic_DNA.
DR EMBL; AY289063; AAP48040.1; -; Genomic_DNA.
DR EMBL; AY289064; AAP48053.1; -; Genomic_DNA.
DR EMBL; AY289065; AAP48066.1; -; Genomic_DNA.
DR EMBL; AY289066; AAP48079.1; -; Genomic_DNA.
DR EMBL; AY289067; AAP48092.1; -; Genomic_DNA.
DR EMBL; AY289068; AAP48105.1; -; Genomic_DNA.
DR EMBL; AY289069; AAP48118.1; -; Genomic_DNA.
DR EMBL; AY289070; AAP48131.1; -; Genomic_DNA.
DR EMBL; AY289071; AAP48144.1; -; Genomic_DNA.
DR EMBL; AY289072; AAP48157.1; -; Genomic_DNA.
DR EMBL; AY289073; AAP48170.1; -; Genomic_DNA.
DR EMBL; AY289074; AAP48183.1; -; Genomic_DNA.
DR EMBL; AY289075; AAP48196.1; -; Genomic_DNA.
DR EMBL; AY289076; AAP48209.1; -; Genomic_DNA.
DR EMBL; AY289077; AAP48222.1; -; Genomic_DNA.
DR EMBL; AY289078; AAP48235.1; -; Genomic_DNA.
DR EMBL; AY289080; AAP48261.1; -; Genomic_DNA.
DR EMBL; AY289081; AAP48274.1; -; Genomic_DNA.
DR EMBL; AY289082; AAP48287.1; -; Genomic_DNA.
DR EMBL; AY289083; AAP48300.1; -; Genomic_DNA.
DR EMBL; AY289084; AAP48313.1; -; Genomic_DNA.
DR EMBL; AY289085; AAP48326.1; -; Genomic_DNA.
DR EMBL; AY289086; AAP48339.1; -; Genomic_DNA.
DR EMBL; AY289087; AAP48352.1; -; Genomic_DNA.
DR EMBL; AY289088; AAP48365.1; -; Genomic_DNA.
DR EMBL; AY289089; AAP48378.1; -; Genomic_DNA.
DR EMBL; AY289090; AAP48391.1; -; Genomic_DNA.
DR EMBL; AY289091; AAP48404.1; -; Genomic_DNA.
DR EMBL; AY289092; AAP48417.1; -; Genomic_DNA.
DR EMBL; AY289093; AAP48429.1; -; Genomic_DNA.
DR EMBL; AY289094; AAP48442.1; -; Genomic_DNA.
DR EMBL; AY289095; AAP48455.1; -; Genomic_DNA.
DR EMBL; AY289096; AAP48468.1; -; Genomic_DNA.
DR EMBL; AY289097; AAP48481.1; -; Genomic_DNA.
DR EMBL; AY289098; AAP48494.1; -; Genomic_DNA.
DR EMBL; AY289099; AAP48507.1; -; Genomic_DNA.
DR EMBL; AY289100; AAP48520.1; -; Genomic_DNA.
DR EMBL; AY289101; AAP48533.1; -; Genomic_DNA.
DR EMBL; AY289102; AAP48546.1; -; Genomic_DNA.
DR EMBL; AY495090; AAR92500.1; -; Genomic_DNA.
DR EMBL; AY495091; AAR92513.1; -; Genomic_DNA.
DR EMBL; AY495092; AAR92526.1; -; Genomic_DNA.
DR EMBL; AY495093; AAR92539.1; -; Genomic_DNA.
DR EMBL; AY495094; AAR92552.1; -; Genomic_DNA.
DR EMBL; AY495095; AAR92565.1; -; Genomic_DNA.
DR EMBL; AY495096; AAR92578.1; -; Genomic_DNA.
DR EMBL; AY495097; AAR92591.1; -; Genomic_DNA.
DR EMBL; AY495098; AAR92604.1; -; Genomic_DNA.
DR EMBL; AY495099; AAR92617.1; -; Genomic_DNA.
DR EMBL; AY495100; AAR92630.1; -; Genomic_DNA.
DR EMBL; AY495101; AAR92643.1; -; Genomic_DNA.
DR EMBL; AY495102; AAR92656.1; -; Genomic_DNA.
DR EMBL; AY495103; AAR92669.1; -; Genomic_DNA.
DR EMBL; AY495104; AAR92682.1; -; Genomic_DNA.
DR EMBL; AY495105; AAR92695.1; -; Genomic_DNA.
DR EMBL; AY495106; AAR92708.1; -; Genomic_DNA.
DR EMBL; AY495107; AAR92721.1; -; Genomic_DNA.
DR EMBL; AY495108; AAR92734.1; -; Genomic_DNA.
DR EMBL; AY495109; AAR92747.1; -; Genomic_DNA.
DR EMBL; AY495110; AAR92760.1; -; Genomic_DNA.
DR EMBL; AY495111; AAR92773.1; -; Genomic_DNA.
DR EMBL; AY495112; AAR92786.1; -; Genomic_DNA.
DR EMBL; AY495113; AAR92799.1; -; Genomic_DNA.
DR EMBL; AY495114; AAR92812.1; -; Genomic_DNA.
DR EMBL; AY495115; AAR92825.1; -; Genomic_DNA.
DR EMBL; AY495116; AAR92838.1; -; Genomic_DNA.
DR EMBL; AY495117; AAR92851.1; -; Genomic_DNA.
DR EMBL; AY495118; AAR92864.1; -; Genomic_DNA.
DR EMBL; AY495119; AAR92877.1; -; Genomic_DNA.
DR EMBL; AY495120; AAR92890.1; -; Genomic_DNA.
DR EMBL; AY495121; AAR92903.1; -; Genomic_DNA.
DR EMBL; AY495122; AAR92916.1; -; Genomic_DNA.
DR EMBL; AY495124; AAR92942.1; -; Genomic_DNA.
DR EMBL; AY495125; AAR92955.1; -; Genomic_DNA.
DR EMBL; AY495126; AAR92968.1; -; Genomic_DNA.
DR EMBL; AY495127; AAR92981.1; -; Genomic_DNA.
DR EMBL; AY495128; AAR92994.1; -; Genomic_DNA.
DR EMBL; AY495129; AAR93007.1; -; Genomic_DNA.
DR EMBL; AY495130; AAR93020.1; -; Genomic_DNA.
DR EMBL; AY495131; AAR93033.1; -; Genomic_DNA.
DR EMBL; AY495132; AAR93046.1; -; Genomic_DNA.
DR EMBL; AY495133; AAR93059.1; -; Genomic_DNA.
DR EMBL; AY495134; AAR93072.1; -; Genomic_DNA.
DR EMBL; AY495135; AAR93085.1; -; Genomic_DNA.
DR EMBL; AY495136; AAR93098.1; -; Genomic_DNA.
DR EMBL; AY495137; AAR93111.1; -; Genomic_DNA.
DR EMBL; AY495138; AAR93124.1; -; Genomic_DNA.
DR EMBL; AY495139; AAR93137.1; -; Genomic_DNA.
DR EMBL; AY495140; AAR93150.1; -; Genomic_DNA.
DR EMBL; AY495141; AAR93163.1; -; Genomic_DNA.
DR EMBL; AY495142; AAR93176.1; -; Genomic_DNA.
DR EMBL; AY495143; AAR93189.1; -; Genomic_DNA.
DR EMBL; AY495144; AAR93202.1; -; Genomic_DNA.
DR EMBL; AY495145; AAR93215.1; -; Genomic_DNA.
DR EMBL; AY495146; AAR93228.1; -; Genomic_DNA.
DR EMBL; AY495147; AAR93241.1; -; Genomic_DNA.
DR EMBL; AY495148; AAR93254.1; -; Genomic_DNA.
DR EMBL; AY495149; AAR93267.1; -; Genomic_DNA.
DR EMBL; AY495150; AAR93280.1; -; Genomic_DNA.
DR EMBL; AY495151; AAR93293.1; -; Genomic_DNA.
DR EMBL; AY495152; AAR93306.1; -; Genomic_DNA.
DR EMBL; AY495153; AAR93319.1; -; Genomic_DNA.
DR EMBL; AY495154; AAR93332.1; -; Genomic_DNA.
DR EMBL; AY495155; AAR93345.1; -; Genomic_DNA.
DR EMBL; AY495156; AAR93358.1; -; Genomic_DNA.
DR EMBL; AY495157; AAR93371.1; -; Genomic_DNA.
DR EMBL; AY495158; AAR93384.1; -; Genomic_DNA.
DR EMBL; AY495159; AAR93397.1; -; Genomic_DNA.
DR EMBL; AY495160; AAR93410.1; -; Genomic_DNA.
DR EMBL; AY495161; AAR93423.1; -; Genomic_DNA.
DR EMBL; AY495162; AAR93436.1; -; Genomic_DNA.
DR EMBL; AY495163; AAR93449.1; -; Genomic_DNA.
DR EMBL; AY495164; AAR93462.1; -; Genomic_DNA.
DR EMBL; AY495165; AAR93475.1; -; Genomic_DNA.
DR EMBL; AY495166; AAR93488.1; -; Genomic_DNA.
DR EMBL; AY495167; AAR93501.1; -; Genomic_DNA.
DR EMBL; AY495168; AAR93514.1; -; Genomic_DNA.
DR EMBL; AY495169; AAR93527.1; -; Genomic_DNA.
DR EMBL; AY495170; AAR93540.1; -; Genomic_DNA.
DR EMBL; AY495171; AAR93553.1; -; Genomic_DNA.
DR EMBL; AY495172; AAR93566.1; -; Genomic_DNA.
DR EMBL; AY495173; AAR93579.1; -; Genomic_DNA.
DR EMBL; AY495174; AAR93592.1; -; Genomic_DNA.
DR EMBL; AY495175; AAR93605.1; -; Genomic_DNA.
DR EMBL; AY495176; AAR93618.1; -; Genomic_DNA.
DR EMBL; AY495177; AAR93631.1; -; Genomic_DNA.
DR EMBL; AY495178; AAR93644.1; -; Genomic_DNA.
DR EMBL; AY495179; AAR93657.1; -; Genomic_DNA.
DR EMBL; AY495180; AAR93670.1; -; Genomic_DNA.
DR EMBL; AY495181; AAR93683.1; -; Genomic_DNA.
DR EMBL; AY495182; AAR93696.1; -; Genomic_DNA.
DR EMBL; AY495183; AAR93709.1; -; Genomic_DNA.
DR EMBL; AY495184; AAR93722.1; -; Genomic_DNA.
DR EMBL; AY495185; AAR93735.1; -; Genomic_DNA.
DR EMBL; AY495186; AAR93748.1; -; Genomic_DNA.
DR EMBL; AY495187; AAR93761.1; -; Genomic_DNA.
DR EMBL; AY495188; AAR93774.1; -; Genomic_DNA.
DR EMBL; AY495189; AAR93787.1; -; Genomic_DNA.
DR EMBL; AY495190; AAR93800.1; -; Genomic_DNA.
DR EMBL; AY495191; AAR93813.1; -; Genomic_DNA.
DR EMBL; AY495192; AAR93826.1; -; Genomic_DNA.
DR EMBL; AY495193; AAR93839.1; -; Genomic_DNA.
DR EMBL; AY495194; AAR93852.1; -; Genomic_DNA.
DR EMBL; AY495195; AAR93865.1; -; Genomic_DNA.
DR EMBL; AY495196; AAR93878.1; -; Genomic_DNA.
DR EMBL; AY495197; AAR93891.1; -; Genomic_DNA.
DR EMBL; AY495198; AAR93904.1; -; Genomic_DNA.
DR EMBL; AY495199; AAR93917.1; -; Genomic_DNA.
DR EMBL; AY495200; AAR93930.1; -; Genomic_DNA.
DR EMBL; AY495201; AAR93943.1; -; Genomic_DNA.
DR EMBL; AY495202; AAR93956.1; -; Genomic_DNA.
DR EMBL; AY495203; AAR93969.1; -; Genomic_DNA.
DR EMBL; AY495204; AAR93982.1; -; Genomic_DNA.
DR EMBL; AY495205; AAR93995.1; -; Genomic_DNA.
DR EMBL; AY495206; AAR94008.1; -; Genomic_DNA.
DR EMBL; AY495207; AAR94021.1; -; Genomic_DNA.
DR EMBL; AY495208; AAR94034.1; -; Genomic_DNA.
DR EMBL; AY495209; AAR94047.1; -; Genomic_DNA.
DR EMBL; AY495210; AAR94060.1; -; Genomic_DNA.
DR EMBL; AY495211; AAR94073.1; -; Genomic_DNA.
DR EMBL; AY495212; AAR94086.1; -; Genomic_DNA.
DR EMBL; AY495213; AAR94099.1; -; Genomic_DNA.
DR EMBL; AY495214; AAR94112.1; -; Genomic_DNA.
DR EMBL; AY495215; AAR94125.1; -; Genomic_DNA.
DR EMBL; AY495216; AAR94138.1; -; Genomic_DNA.
DR EMBL; AY495217; AAR94151.1; -; Genomic_DNA.
DR EMBL; AY495218; AAR94164.1; -; Genomic_DNA.
DR EMBL; AY495219; AAR94177.1; -; Genomic_DNA.
DR EMBL; AY495220; AAR94190.1; -; Genomic_DNA.
DR EMBL; AY495221; AAR94203.1; -; Genomic_DNA.
DR EMBL; AY495222; AAR94216.1; -; Genomic_DNA.
DR EMBL; AY495223; AAR94229.1; -; Genomic_DNA.
DR EMBL; AY495224; AAR94242.1; -; Genomic_DNA.
DR EMBL; AY495225; AAR94255.1; -; Genomic_DNA.
DR EMBL; AY495227; AAR94281.1; -; Genomic_DNA.
DR EMBL; AY495228; AAR94294.1; -; Genomic_DNA.
DR EMBL; AY495229; AAR94307.1; -; Genomic_DNA.
DR EMBL; AY495230; AAR94320.1; -; Genomic_DNA.
DR EMBL; AY495231; AAR94333.1; -; Genomic_DNA.
DR EMBL; AY495232; AAR94346.1; -; Genomic_DNA.
DR EMBL; AY495233; AAR94359.1; -; Genomic_DNA.
DR EMBL; AY495234; AAR94372.1; -; Genomic_DNA.
DR EMBL; AY495235; AAR94385.1; -; Genomic_DNA.
DR EMBL; AY495236; AAR94398.1; -; Genomic_DNA.
DR EMBL; AY495237; AAR94411.1; -; Genomic_DNA.
DR EMBL; AY495238; AAR94424.1; -; Genomic_DNA.
DR EMBL; AY495239; AAR94437.1; -; Genomic_DNA.
DR EMBL; AY495240; AAR94450.1; -; Genomic_DNA.
DR EMBL; AY495241; AAR94463.1; -; Genomic_DNA.
DR EMBL; AY495242; AAR94476.1; -; Genomic_DNA.
DR EMBL; AY495243; AAR94489.1; -; Genomic_DNA.
DR EMBL; AY495244; AAR94502.1; -; Genomic_DNA.
DR EMBL; AY495245; AAR94515.1; -; Genomic_DNA.
DR EMBL; AY495246; AAR94528.1; -; Genomic_DNA.
DR EMBL; AY495247; AAR94541.1; -; Genomic_DNA.
DR EMBL; AY495248; AAR94554.1; -; Genomic_DNA.
DR EMBL; AY495249; AAR94567.1; -; Genomic_DNA.
DR EMBL; AY495250; AAR94580.1; -; Genomic_DNA.
DR EMBL; AY495251; AAR94593.1; -; Genomic_DNA.
DR EMBL; AY495252; AAR94606.1; -; Genomic_DNA.
DR EMBL; AY495253; AAR94619.1; -; Genomic_DNA.
DR EMBL; AY495254; AAR94632.1; -; Genomic_DNA.
DR EMBL; AY495255; AAR94645.1; -; Genomic_DNA.
DR EMBL; AY495256; AAR94658.1; -; Genomic_DNA.
DR EMBL; AY495257; AAR94671.1; -; Genomic_DNA.
DR EMBL; AY495259; AAR94697.1; -; Genomic_DNA.
DR EMBL; AY495260; AAR94710.1; -; Genomic_DNA.
DR EMBL; AY495261; AAR94723.1; -; Genomic_DNA.
DR EMBL; AY495262; AAR94736.1; -; Genomic_DNA.
DR EMBL; AY495263; AAR94749.1; -; Genomic_DNA.
DR EMBL; AY495264; AAR94762.1; -; Genomic_DNA.
DR EMBL; AY495265; AAR94775.1; -; Genomic_DNA.
DR EMBL; AY495266; AAR94788.1; -; Genomic_DNA.
DR EMBL; AY495267; AAR94801.1; -; Genomic_DNA.
DR EMBL; AY495268; AAR94814.1; -; Genomic_DNA.
DR EMBL; AY495269; AAR94827.1; -; Genomic_DNA.
DR EMBL; AY495270; AAR94840.1; -; Genomic_DNA.
DR EMBL; AY495271; AAR94853.1; -; Genomic_DNA.
DR EMBL; AY495272; AAR94866.1; -; Genomic_DNA.
DR EMBL; AY495273; AAR94879.1; -; Genomic_DNA.
DR EMBL; AY495274; AAR94892.1; -; Genomic_DNA.
DR EMBL; AY495275; AAR94905.1; -; Genomic_DNA.
DR EMBL; AY495277; AAR94931.1; -; Genomic_DNA.
DR EMBL; AY495278; AAR94944.1; -; Genomic_DNA.
DR EMBL; AY495279; AAR94957.1; -; Genomic_DNA.
DR EMBL; AY495280; AAR94970.1; -; Genomic_DNA.
DR EMBL; AY495281; AAR94983.1; -; Genomic_DNA.
DR EMBL; AY495282; AAR94996.1; -; Genomic_DNA.
DR EMBL; AY495284; AAR95022.1; -; Genomic_DNA.
DR EMBL; AY495285; AAR95035.1; -; Genomic_DNA.
DR EMBL; AY495286; AAR95048.1; -; Genomic_DNA.
DR EMBL; AY495287; AAR95061.1; -; Genomic_DNA.
DR EMBL; AY495288; AAR95074.1; -; Genomic_DNA.
DR EMBL; AY495289; AAR95087.1; -; Genomic_DNA.
DR EMBL; AY495290; AAR95100.1; -; Genomic_DNA.
DR EMBL; AY495291; AAR95113.1; -; Genomic_DNA.
DR EMBL; AY495292; AAR95126.1; -; Genomic_DNA.
DR EMBL; AY495293; AAR95139.1; -; Genomic_DNA.
DR EMBL; AY495294; AAR95152.1; -; Genomic_DNA.
DR EMBL; AY495295; AAR95165.1; -; Genomic_DNA.
DR EMBL; AY495296; AAR95178.1; -; Genomic_DNA.
DR EMBL; AY495297; AAR95191.1; -; Genomic_DNA.
DR EMBL; AY495298; AAR95204.1; -; Genomic_DNA.
DR EMBL; AY495299; AAR95217.1; -; Genomic_DNA.
DR EMBL; AY495301; AAR95243.1; -; Genomic_DNA.
DR EMBL; AY495302; AAR95256.1; -; Genomic_DNA.
DR EMBL; AY495304; AAR95282.1; -; Genomic_DNA.
DR EMBL; AY495305; AAR95295.1; -; Genomic_DNA.
DR EMBL; AY495306; AAR95308.1; -; Genomic_DNA.
DR EMBL; AY495307; AAR95321.1; -; Genomic_DNA.
DR EMBL; AY495308; AAR95334.1; -; Genomic_DNA.
DR EMBL; AY495309; AAR95347.1; -; Genomic_DNA.
DR EMBL; AY495310; AAR95360.1; -; Genomic_DNA.
DR EMBL; AY495311; AAR95373.1; -; Genomic_DNA.
DR EMBL; AY495312; AAR95386.1; -; Genomic_DNA.
DR EMBL; AY495313; AAR95399.1; -; Genomic_DNA.
DR EMBL; AY495314; AAR95412.1; -; Genomic_DNA.
DR EMBL; AY495315; AAR95425.1; -; Genomic_DNA.
DR EMBL; AY495316; AAR95438.1; -; Genomic_DNA.
DR EMBL; AY495317; AAR95451.1; -; Genomic_DNA.
DR EMBL; AY495318; AAR95464.1; -; Genomic_DNA.
DR EMBL; AY495319; AAR95477.1; -; Genomic_DNA.
DR EMBL; AY495320; AAR95490.1; -; Genomic_DNA.
DR EMBL; AY495322; AAR95516.1; -; Genomic_DNA.
DR EMBL; AY495323; AAR95529.1; -; Genomic_DNA.
DR EMBL; AY495324; AAR95542.1; -; Genomic_DNA.
DR EMBL; AY495325; AAR95555.1; -; Genomic_DNA.
DR EMBL; AY495326; AAR95568.1; -; Genomic_DNA.
DR EMBL; AY495327; AAR95581.1; -; Genomic_DNA.
DR EMBL; AY495328; AAR95594.1; -; Genomic_DNA.
DR EMBL; AY495329; AAR95607.1; -; Genomic_DNA.
DR EMBL; AY495330; AAR95620.1; -; Genomic_DNA.
DR PIR; A01062; PWHU8.
DR RefSeq; YP_003024030.1; NC_012920.1.
DR AlphaFoldDB; P03928; -.
DR SMR; P03928; -.
DR BioGRID; 110613; 41.
DR ComplexPortal; CPX-6151; Mitochondrial proton-transporting ATP synthase complex.
DR CORUM; P03928; -.
DR IntAct; P03928; 24.
DR MINT; P03928; -.
DR STRING; 9606.ENSP00000355265; -.
DR TCDB; 3.A.2.1.15; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR iPTMnet; P03928; -.
DR PhosphoSitePlus; P03928; -.
DR SwissPalm; P03928; -.
DR BioMuta; MT-ATP8; -.
DR DMDM; 114483; -.
DR EPD; P03928; -.
DR jPOST; P03928; -.
DR MassIVE; P03928; -.
DR PaxDb; P03928; -.
DR PeptideAtlas; P03928; -.
DR PRIDE; P03928; -.
DR ProteomicsDB; 51618; -.
DR TopDownProteomics; P03928; -.
DR Antibodypedia; 64403; 42 antibodies from 13 providers.
DR DNASU; 4509; -.
DR Ensembl; ENST00000361851.1; ENSP00000355265.1; ENSG00000228253.1.
DR GeneID; 4509; -.
DR KEGG; hsa:4509; -.
DR CTD; 4509; -.
DR DisGeNET; 4509; -.
DR GeneCards; MT-ATP8; -.
DR HGNC; HGNC:7415; MT-ATP8.
DR HPA; ENSG00000228253; Tissue enhanced (heart).
DR MalaCards; MT-ATP8; -.
DR MIM; 500006; phenotype.
DR MIM; 516070; gene+phenotype.
DR neXtProt; NX_P03928; -.
DR OpenTargets; ENSG00000228253; -.
DR Orphanet; 254913; Isolated ATP synthase deficiency.
DR Orphanet; 480; Kearns-Sayre syndrome.
DR Orphanet; 397750; Periodic paralysis with later-onset distal motor neuropathy.
DR PharmGKB; PA31222; -.
DR VEuPathDB; HostDB:ENSG00000228253; -.
DR eggNOG; ENOG502T21P; Eukaryota.
DR GeneTree; ENSGT00390000008771; -.
DR HOGENOM; CLU_2811757_0_0_1; -.
DR InParanoid; P03928; -.
DR OMA; LDTSTWF; -.
DR OrthoDB; 1621322at2759; -.
DR PhylomeDB; P03928; -.
DR BioCyc; MetaCyc:HS00025-MON; -.
DR PathwayCommons; P03928; -.
DR Reactome; R-HSA-163210; Formation of ATP by chemiosmotic coupling.
DR Reactome; R-HSA-8949613; Cristae formation.
DR SignaLink; P03928; -.
DR SIGNOR; P03928; -.
DR BioGRID-ORCS; 4509; 0 hits in 1 CRISPR screen.
DR ChiTaRS; ATP8; human.
DR GeneWiki; MT-ATP8; -.
DR GenomeRNAi; 4509; -.
DR Pharos; P03928; Tbio.
DR PRO; PR:P03928; -.
DR Proteomes; UP000005640; Mitochondrion.
DR RNAct; P03928; protein.
DR Bgee; ENSG00000228253; Expressed in right hemisphere of cerebellum and 94 other tissues.
DR ExpressionAtlas; P03928; baseline and differential.
DR Genevisible; P03928; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
DR GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IC:ComplexPortal.
DR GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; IDA:UniProtKB.
DR InterPro; IPR039017; ATP8_mammal.
DR InterPro; IPR001421; ATP8_metazoa.
DR PANTHER; PTHR13722; PTHR13722; 1.
DR Pfam; PF00895; ATP-synt_8; 1.
PE 1: Evidence at protein level;
KW Acetylation; ATP synthesis; Cardiomyopathy; CF(0); Disease variant;
KW Hydrogen ion transport; Ion transport; Membrane; Mitochondrion;
KW Primary mitochondrial disease; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..68
FT /note="ATP synthase protein 8"
FT /id="PRO_0000195536"
FT TRANSMEM 8..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 54
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P03930"
FT MOD_RES 54
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P03930"
FT MOD_RES 57
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P03930"
FT VARIANT 17
FT /note="L -> P (in dbSNP:rs1603221470)"
FT /evidence="ECO:0000269|PubMed:1757091"
FT /id="VAR_008563"
FT VARIANT 21
FT /note="F -> S"
FT /evidence="ECO:0000269|PubMed:1757091"
FT /id="VAR_008564"
FT VARIANT 28
FT /note="M -> T (in dbSNP:rs879056797)"
FT /evidence="ECO:0000269|PubMed:9461455"
FT /id="VAR_008565"
FT VARIANT 55
FT /note="W -> R (in MC5DM2 and CMHI; dbSNP:rs387906422)"
FT /evidence="ECO:0000269|PubMed:19188198"
FT /id="VAR_069527"
FT CONFLICT 10
FT /note="P -> S (in Ref. 3; AAP90483)"
FT /evidence="ECO:0000305"
FT CONFLICT 32
FT /note="N -> S (in Ref. 2; BAA07294)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 68 AA; 7992 MW; 7D307E513AD76936 CRC64;
MPQLNTTVWP TMITPMLLTL FLITQLKMLN TNYHLPPSPK PMKMKNYNKP WEPKWTKICS
LHSLPPQS
