ATP8_KLULA
ID ATP8_KLULA Reviewed; 48 AA.
AC Q00608;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=ATP synthase protein 8;
DE AltName: Full=A6L;
DE AltName: Full=F-ATPase subunit 8;
GN Name=ATP8;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 90735 / K8;
RX PubMed=1657415; DOI=10.1007/bf00312772;
RA Hardy C.M., Clark-Walker G.D.;
RT "Nucleotide sequence of the COX1 gene in Kluyveromyces lactis mitochondrial
RT DNA: evidence for recent horizontal transfer of a group II intron.";
RL Curr. Genet. 20:99-114(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 76492 / CBS 2359/152 / CLIB 210;
RX PubMed=15691736; DOI=10.1016/j.femsyr.2004.09.003;
RA Zivanovic Y., Wincker P., Vacherie B., Bolotin-Fukuhara M., Fukuhara H.;
RT "Complete nucleotide sequence of the mitochondrial DNA from Kluyveromyces
RT lactis.";
RL FEMS Yeast Res. 5:315-322(2005).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Part of the complex
CC F(0) domain. Minor subunit located with subunit a in the membrane (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the ATPase protein 8 family. {ECO:0000305}.
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DR EMBL; X57546; CAA40770.1; -; Genomic_DNA.
DR EMBL; AY654900; AAT64952.1; -; Genomic_DNA.
DR PIR; S17994; S17994.
DR RefSeq; YP_054499.1; NC_006077.1.
DR AlphaFoldDB; Q00608; -.
DR SMR; Q00608; -.
DR STRING; 284590.Q00608; -.
DR GeneID; 2914080; -.
DR KEGG; kla:KllafMp04; -.
DR InParanoid; Q00608; -.
DR Proteomes; UP000000598; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR InterPro; IPR009230; ATP_synth_su8_fun.
DR PANTHER; PTHR36101; PTHR36101; 1.
DR Pfam; PF05933; Fun_ATP-synt_8; 1.
PE 3: Inferred from homology;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..48
FT /note="ATP synthase protein 8"
FT /id="PRO_0000195601"
FT TRANSMEM 13..32
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 48 AA; 5711 MW; 9F5E8A929D94F8C3 CRC64;
MPQLVPFYFL NQLVYGFALV TILLVLFAQY FLPQILRLYV SRLFISKL
