ID   PYRF_CALS4              Reviewed;         307 AA.
AC   P58883;
DT   24-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   24-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Orotidine 5'-phosphate decarboxylase;
DE            EC=4.1.1.23;
DE   AltName: Full=OMP decarboxylase;
DE            Short=OMPDCase;
DE            Short=OMPdecase;
GN   Name=pyrF; OrderedLocusNames=TTE1532;
OS   Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS   11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Caldanaerobacter.
OX   NCBI_TaxID=273068;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX   PubMed=11997336; DOI=10.1101/gr.219302;
RA   Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA   Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA   Wang J., Yu J., Yang H.;
RT   "A complete sequence of the T. tengcongensis genome.";
RL   Genome Res. 12:689-700(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC         Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 2/2.
CC   -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM24743.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE008691; AAM24743.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041587324.1; NC_003869.1.
DR   AlphaFoldDB; P58883; -.
DR   SMR; P58883; -.
DR   STRING; 273068.TTE1532; -.
DR   EnsemblBacteria; AAM24743; AAM24743; TTE1532.
DR   KEGG; tte:TTE1532; -.
DR   eggNOG; COG0284; Bacteria.
DR   HOGENOM; CLU_060704_1_1_9; -.
DR   OMA; QSAFFER; -.
DR   OrthoDB; 1181405at2; -.
DR   UniPathway; UPA00070; UER00120.
DR   Proteomes; UP000000555; Chromosome.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01215; OMPdecase_type2; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011995; OMPdecase_type-2.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR43375; PTHR43375; 1.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   TIGRFAMs; TIGR02127; pyrF_sub2; 1.
PE   3: Inferred from homology;
KW   Decarboxylase; Lyase; Pyrimidine biosynthesis; Reference proteome.
FT   CHAIN           1..307
FT                   /note="Orotidine 5'-phosphate decarboxylase"
FT                   /id="PRO_0000134636"
FT   ACT_SITE        106
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   307 AA;  34399 MW;  F1D89D49BDFEFE01 CRC64;
     MFVDRLIESV KAKKTPVVVG LDPRIEMIPD FIKEEAFRRK GNGVEGIAEA MYLFNKGIID
     AVYDLIPAVK IQVAFYEAYG IEGFKAFFRT AEYAKSLGLI VIADVKRGDI QDVAKMYSKA
     YLQNPLFDAI TVNPYMGEDS MVPYLEDVEK FGKGIFVLVK TSNRSSKDVQ DIETKKGGYV
     YQEVAKMISR LSKVIVGKYG YSSIGAVVGA TYPFEAKILR EEMPRCYFLV PGYGAQGATA
     EDVVNCFDEE GYGAIINSSR GVIYAYRSDF WKEAYSEYEY GQAAREEVIL MTGMINNALV
     KRKYIAS