AAEA_YERPE
ID AAEA_YERPE Reviewed; 311 AA.
AC Q8ZAU9; Q0WAW9; Q74PP0; Q7CL75;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeA {ECO:0000255|HAMAP-Rule:MF_01544};
DE Short=pHBA efflux pump protein A {ECO:0000255|HAMAP-Rule:MF_01544};
GN Name=aaeA {ECO:0000255|HAMAP-Rule:MF_01544};
GN OrderedLocusNames=YPO3685, y0178, YP_3858;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Forms an efflux pump with AaeB. {ECO:0000255|HAMAP-
CC Rule:MF_01544}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01544}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01544}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000255|HAMAP-Rule:MF_01544}.
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DR EMBL; AL590842; CAL22273.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM83772.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS64003.1; -; Genomic_DNA.
DR PIR; AF0448; AF0448.
DR RefSeq; WP_002210094.1; NZ_WHLN01000035.1.
DR RefSeq; YP_002348569.1; NC_003143.1.
DR AlphaFoldDB; Q8ZAU9; -.
DR SMR; Q8ZAU9; -.
DR STRING; 214092.YPO3685; -.
DR PaxDb; Q8ZAU9; -.
DR DNASU; 1145125; -.
DR EnsemblBacteria; AAM83772; AAM83772; y0178.
DR EnsemblBacteria; AAS64003; AAS64003; YP_3858.
DR GeneID; 66844034; -.
DR KEGG; ype:YPO3685; -.
DR KEGG; ypk:y0178; -.
DR KEGG; ypm:YP_3858; -.
DR PATRIC; fig|214092.21.peg.4192; -.
DR eggNOG; COG1566; Bacteria.
DR HOGENOM; CLU_018816_15_2_6; -.
DR OMA; EVEPTFN; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01544; AaeA; 1.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR022871; PHBA_efflux_pump_AaeA.
DR InterPro; IPR006143; RND_pump_MFP.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR TIGRFAMs; TIGR01730; RND_mfp; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..311
FT /note="p-hydroxybenzoic acid efflux pump subunit AaeA"
FT /id="PRO_0000201858"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01544"
SQ SEQUENCE 311 AA; 34315 MW; 8735684261C3CC00 CRC64;
MSTFSLKIIR VGITVLVVVL AVIAIFNVWA FYTESPWTRD AKFTADVVAI APDVSGLLTE
VPVKDNQLVQ KGQILFVIDQ PRYQQALAEA EADVAYYQTL AAEKQRESSR RHRLGIQALS
QEEIDQASNV LQTVQHQLAK AIAVRDLARL DLERTTVRAP AEGWVTNLNV HAGEFINRGA
TAVALVKKDT FYILAYLEET KLEGVKPGYR AEITPLGSNR ILHGTVDSIS AGVTNSSSSA
DSKGLATIDN NLEWVRLAQR VPVKIHLDSE DQQYLYPAGT TATVVITGPN DRDPHQASPM
TKLMHRLREF G
