PYRF_MYXXD
ID PYRF_MYXXD Reviewed; 288 AA.
AC P24220; Q1CZX6;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Orotidine 5'-phosphate decarboxylase;
DE EC=4.1.1.23;
DE AltName: Full=OMP decarboxylase;
DE Short=OMPDCase;
DE Short=OMPdecase;
GN Name=pyrF; Synonyms=uraA; OrderedLocusNames=MXAN_5910;
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC Cystobacterineae; Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1730672; DOI=10.1016/s0021-9258(18)48357-3;
RA Kimsey H.H., Kaiser D.;
RT "The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus.
RT Comparison to the OMP decarboxylase gene family.";
RL J. Biol. Chem. 267:819-824(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622;
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2.
CC -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC {ECO:0000305}.
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DR EMBL; M79324; AAA25401.1; -; Genomic_DNA.
DR EMBL; CP000113; ABF86406.1; -; Genomic_DNA.
DR PIR; B41768; B41768.
DR RefSeq; WP_011555861.1; NC_008095.1.
DR AlphaFoldDB; P24220; -.
DR SMR; P24220; -.
DR STRING; 246197.MXAN_5910; -.
DR EnsemblBacteria; ABF86406; ABF86406; MXAN_5910.
DR GeneID; 41363148; -.
DR KEGG; mxa:MXAN_5910; -.
DR eggNOG; COG0284; Bacteria.
DR HOGENOM; CLU_060704_0_0_7; -.
DR OMA; QSAFFER; -.
DR OrthoDB; 1181405at2; -.
DR UniPathway; UPA00070; UER00120.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_01215; OMPdecase_type2; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR018089; OMPdecase_AS.
DR InterPro; IPR011995; OMPdecase_type-2.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR43375; PTHR43375; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR TIGRFAMs; TIGR02127; pyrF_sub2; 1.
DR PROSITE; PS00156; OMPDECASE; 1.
PE 3: Inferred from homology;
KW Decarboxylase; Lyase; Pyrimidine biosynthesis; Reference proteome.
FT CHAIN 1..288
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /id="PRO_0000134632"
FT ACT_SITE 99
FT /note="Proton donor"
FT /evidence="ECO:0000250"
SQ SEQUENCE 288 AA; 30468 MW; 341E002170214DF9 CRC64;
MTTPQPFAHR FSQLAEQRSP FCLGIDPSRD LLTRWGLPDN ARGLRDFCER VADAAGSSVA
VVKPQSAFFE RHGPEGLQVL QELMRRFKSV GTLTLLDVKR GDIGSTMEAY AETVFGEGSA
YEADAATFTA YLGLGALLKT LERARASGAA AFLVVRSSNP EGTSLQMSRG EDGRTVAEAL
ADGLRAFNEK PGQDAAPVAG AVMGATLPDS DRGVIERLGG ALLLTPGIGA QGAGFDDLKR
LFAGREAQVI PTATRSVLEA GPDTAALRQA LERHLAPARA FRATARPS
