ID   AAEA_YERPN              Reviewed;         311 AA.
AC   Q1CDW6; D1Q1G1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeA {ECO:0000255|HAMAP-Rule:MF_01544};
DE            Short=pHBA efflux pump protein A {ECO:0000255|HAMAP-Rule:MF_01544};
GN   Name=aaeA {ECO:0000255|HAMAP-Rule:MF_01544}; OrderedLocusNames=YPN_3487;
GN   ORFNames=YP516_3960;
OS   Yersinia pestis bv. Antiqua (strain Nepal516).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=377628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RA   Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA   Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R.,
RA   Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.;
RT   "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms an efflux pump with AaeB. {ECO:0000255|HAMAP-
CC       Rule:MF_01544}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01544}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01544}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01544}.
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DR   EMBL; CP000305; ABG19814.1; -; Genomic_DNA.
DR   EMBL; ACNQ01000019; EEO74364.1; -; Genomic_DNA.
DR   RefSeq; WP_002210094.1; NZ_ACNQ01000019.1.
DR   AlphaFoldDB; Q1CDW6; -.
DR   SMR; Q1CDW6; -.
DR   EnsemblBacteria; ABG19814; ABG19814; YPN_3487.
DR   GeneID; 66844034; -.
DR   KEGG; ypn:YPN_3487; -.
DR   HOGENOM; CLU_018816_15_2_6; -.
DR   OMA; EVEPTFN; -.
DR   Proteomes; UP000008936; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01544; AaeA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022871; PHBA_efflux_pump_AaeA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..311
FT                   /note="p-hydroxybenzoic acid efflux pump subunit AaeA"
FT                   /id="PRO_0000300560"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01544"
SQ   SEQUENCE   311 AA;  34315 MW;  8735684261C3CC00 CRC64;
     MSTFSLKIIR VGITVLVVVL AVIAIFNVWA FYTESPWTRD AKFTADVVAI APDVSGLLTE
     VPVKDNQLVQ KGQILFVIDQ PRYQQALAEA EADVAYYQTL AAEKQRESSR RHRLGIQALS
     QEEIDQASNV LQTVQHQLAK AIAVRDLARL DLERTTVRAP AEGWVTNLNV HAGEFINRGA
     TAVALVKKDT FYILAYLEET KLEGVKPGYR AEITPLGSNR ILHGTVDSIS AGVTNSSSSA
     DSKGLATIDN NLEWVRLAQR VPVKIHLDSE DQQYLYPAGT TATVVITGPN DRDPHQASPM
     TKLMHRLREF G