ATP8_XENLA
ID ATP8_XENLA Reviewed; 55 AA.
AC P03931;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=ATP synthase protein 8;
DE AltName: Full=A6L;
DE AltName: Full=F-ATPase subunit 8;
GN Name=mt-atp8; Synonyms=atp8, atpase8, mtatp8;
OS Xenopus laevis (African clawed frog).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=4019494; DOI=10.1016/s0021-9258(17)39303-1;
RA Roe B.A., Ma D.-P., Wilson R.K., Wong J.F.-H.;
RT "The complete nucleotide sequence of the Xenopus laevis mitochondrial
RT genome.";
RL J. Biol. Chem. 260:9759-9774(1985).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Part of the complex
CC F(0) domain. Minor subunit located with subunit a in the membrane (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the ATPase protein 8 family. {ECO:0000305}.
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DR EMBL; M10217; AAA66462.1; -; Genomic_DNA.
DR PIR; A01065; PWXL8.
DR RefSeq; NP_008138.1; NC_001573.1.
DR AlphaFoldDB; P03931; -.
DR SMR; P03931; -.
DR BioGRID; 106516; 1.
DR GeneID; 2642082; -.
DR KEGG; xla:2642082; -.
DR CTD; 4509; -.
DR Xenbase; XB-GENE-6251963; atp8.L.
DR OrthoDB; 1621322at2759; -.
DR Proteomes; UP000186698; Mitochondrion MT.
DR Bgee; 2642082; Expressed in egg cell and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR InterPro; IPR001421; ATP8_metazoa.
DR Pfam; PF00895; ATP-synt_8; 1.
PE 3: Inferred from homology;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..55
FT /note="ATP synthase protein 8"
FT /id="PRO_0000195594"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 35..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 55 AA; 6531 MW; 8AB4FE1050260994 CRC64;
MPQLNPGPWF LILIFSWLVL LTFIPPKVLK HKAFNEPTTQ TTEKSKPNPW NWPWT