ATP8_YEAST
ID ATP8_YEAST Reviewed; 48 AA.
AC P00856; A0A0A7P362;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=ATP synthase protein 8;
DE AltName: Full=A6L;
DE AltName: Full=ATP-associated protein 1;
DE AltName: Full=F-ATPase subunit 8;
GN Name=ATP8; Synonyms=AAP1; OrderedLocusNames=Q0080;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6223276; DOI=10.1093/nar/11.13.4435;
RA McReadie I.G., Novitski C.E., Maxwell R.J., John U., Ooi B.-G.,
RA McMullen G.L., Lukins H.B., Linnane A.W., Nagley P.;
RT "Biogenesis of mitochondria: the mitochondrial gene (aap1) coding for
RT mitochondrial ATPase subunit 8 in Saccharomyces cerevisiae.";
RL Nucleic Acids Res. 11:4435-4451(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6387398; DOI=10.1007/bf00328059;
RA Simon M., Faye G.;
RT "Organization and processing of the mitochondrial oxi3/oli2 multigenic
RT transcript in yeast.";
RL Mol. Gen. Genet. 196:266-274(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9872396; DOI=10.1016/s0014-5793(98)01467-7;
RA Foury F., Roganti T., Lecrenier N., Purnelle B.;
RT "The complete sequence of the mitochondrial genome of Saccharomyces
RT cerevisiae.";
RL FEBS Lett. 440:325-331(1998).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Part of the complex
CC F(0) domain. Minor subunit located with subunit a in the membrane (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. In yeast, the dimeric form
CC of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta,
CC epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j
CC and k.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the ATPase protein 8 family. {ECO:0000305}.
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DR EMBL; X00895; CAA25423.1; -; Genomic_DNA.
DR EMBL; X00960; CAA25473.1; -; Genomic_DNA.
DR EMBL; KP263414; AIZ98888.1; -; Genomic_DNA.
DR PIR; S05820; EWBY8.
DR RefSeq; NP_009312.1; NC_001224.1.
DR RefSeq; YP_009144707.1; NC_027264.1.
DR PDB; 6B2Z; EM; 3.60 A; A/L=1-48.
DR PDB; 6B8H; EM; 3.60 A; A/V=1-48.
DR PDB; 6CP3; EM; 3.80 A; 8=1-48.
DR PDB; 6CP5; EM; 4.20 A; 8=1-48.
DR PDB; 6CP6; EM; 3.60 A; 8=1-48.
DR PDB; 6CP7; EM; 4.10 A; 8=1-48.
DR PDB; 6WTD; EM; 4.20 A; 8=1-48.
DR PDBsum; 6B2Z; -.
DR PDBsum; 6B8H; -.
DR PDBsum; 6CP3; -.
DR PDBsum; 6CP5; -.
DR PDBsum; 6CP6; -.
DR PDBsum; 6CP7; -.
DR PDBsum; 6WTD; -.
DR AlphaFoldDB; P00856; -.
DR SMR; P00856; -.
DR BioGRID; 34792; 14.
DR ComplexPortal; CPX-3281; Mitochondrial proton-transporting ATP synthase complex.
DR DIP; DIP-3040N; -.
DR IntAct; P00856; 4.
DR STRING; 4932.Q0080; -.
DR TCDB; 3.A.2.1.3; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR PaxDb; P00856; -.
DR PRIDE; P00856; -.
DR EnsemblFungi; Q0080_mRNA; Q0080; Q0080.
DR GeneID; 24573117; -.
DR GeneID; 854600; -.
DR KEGG; sce:Q0080; -.
DR SGD; S000007267; ATP8.
DR VEuPathDB; FungiDB:Q0080; -.
DR eggNOG; ENOG502RM7C; Eukaryota.
DR HOGENOM; CLU_214588_0_0_1; -.
DR InParanoid; P00856; -.
DR BioCyc; YEAST:G3O-34378-MON; -.
DR PRO; PR:P00856; -.
DR Proteomes; UP000002311; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:ComplexPortal.
DR GO; GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; IC:ComplexPortal.
DR GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IMP:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IDA:SGD.
DR InterPro; IPR009230; ATP_synth_su8_fun.
DR Pfam; PF05933; Fun_ATP-synt_8; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP synthesis; CF(0); Hydrogen ion transport; Ion transport;
KW Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..48
FT /note="ATP synthase protein 8"
FT /id="PRO_0000195607"
FT TRANSMEM 13..32
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 48 AA; 5822 MW; 7E5483656089A4C2 CRC64;
MPQLVPFYFM NQLTYGFLLM ITLLILFSQF FLPMILRLYV SRLFISKL
