ID   AAEB_ECO8A              Reviewed;         655 AA.
AC   B7M0V2;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeB {ECO:0000255|HAMAP-Rule:MF_01545};
DE            Short=pHBA efflux pump protein B {ECO:0000255|HAMAP-Rule:MF_01545};
GN   Name=aaeB {ECO:0000255|HAMAP-Rule:MF_01545}; OrderedLocusNames=ECIAI1_3382;
OS   Escherichia coli O8 (strain IAI1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585034;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAI1;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Forms an efflux pump with AaeA. Could function as a metabolic
CC       relief valve, allowing to eliminate certain compounds when they
CC       accumulate to high levels in the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01545}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01545}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01545}.
CC   -!- INDUCTION: Positively coregulated with aaeA and aaeX by AaeR.
CC       {ECO:0000255|HAMAP-Rule:MF_01545}.
CC   -!- SIMILARITY: Belongs to the aromatic acid exporter ArAE (TC 2.A.85)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01545}.
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DR   EMBL; CU928160; CAR00196.1; -; Genomic_DNA.
DR   RefSeq; WP_000510962.1; NC_011741.1.
DR   AlphaFoldDB; B7M0V2; -.
DR   GeneID; 66672864; -.
DR   KEGG; ecr:ECIAI1_3382; -.
DR   HOGENOM; CLU_027647_0_0_6; -.
DR   OMA; MITQACE; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046942; P:carboxylic acid transport; IEA:InterPro.
DR   HAMAP; MF_01545; AaeB; 1.
DR   InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR   InterPro; IPR023706; PHBA_efflux_pump_AaeB.
DR   PANTHER; PTHR30509:SF10; PTHR30509:SF10; 1.
DR   Pfam; PF04632; FUSC; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..655
FT                   /note="p-hydroxybenzoic acid efflux pump subunit AaeB"
FT                   /id="PRO_1000146735"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
SQ   SEQUENCE   655 AA;  73611 MW;  41F02829C82454E6 CRC64;
     MGIFSIANQH IRFAVKLATA IVLALFVGFH FQLETPRWAV LTAAIVAAGP AFAAGGEPYS
     GAIRYRGFLR IIGTFIGCIA GLVIIIAMIR APLLMILVCC IWAGFCTWIS SLVRIENSYA
     WGLAGYTALI IVITIQPEPL LTPQFAVERC SEIVIGIVCA IMADLLFSPR SIKQEVDREL
     ESLLVAQYQL MQLCIKHGDG EVVDKAWGDL VRRTTALQGM RSNLNMESSR WARANRRLKA
     INTLSLTLIT QSCETYLIQN TRPELITDTF REFFDTPVET AQDVHKQLKR LRRVIAWTGE
     RETPVTIYSW VAAATRYQLL KRGVISNTKI NATEEEILQG EPEVKVESAE RHHAMVNFWR
     TTLSCILGTL FWLWTGWTSG SGAMVMIAVV TSLAMRLPNP RMVAIDFIYG TLAALPLGLL
     YFLVIIPNTQ QSMLLLCISL AVLGFFLGIE VQKRRLGSMG ALASTINIIV LDNPMTFHFS
     QFLDSALGQI VGCVLAFTVI LLVRDKSRDR TGRVLLNQFV SAAVSAMTTN VARRKENHLP
     ALYQQLFLLM NKFPGDLPKF RLALTMIIAH QRLRDAPIPV NEDLSAFHRQ MRRTADHVIS
     ARSDDKRRRY FGQLLEELEI YQEKLRIWQA PPQVTEPVHR LAGMLHKYQH ALTDS