ID   PYRP_BACCL              Reviewed;         432 AA.
AC   P41006;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Uracil permease;
DE   AltName: Full=Uracil transporter;
GN   Name=pyrP;
OS   Bacillus caldolyticus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=1394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 405 / NBRC 15313 / YP-T;
RX   PubMed=8206848; DOI=10.1128/jb.176.12.3698-3707.1994;
RA   Ghim S.Y., Neuhard J.;
RT   "The pyrimidine biosynthesis operon of the thermophile Bacillus
RT   caldolyticus includes genes for uracil phosphoribosyltransferase and uracil
RT   permease.";
RL   J. Bacteriol. 176:3698-3707(1994).
CC   -!- FUNCTION: Transport of uracil in the cell.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000305}.
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DR   EMBL; X76083; CAA53697.1; -; Genomic_DNA.
DR   PIR; S38893; S38893.
DR   RefSeq; WP_011230648.1; NZ_CP025074.1.
DR   AlphaFoldDB; P41006; -.
DR   SMR; P41006; -.
DR   PRIDE; P41006; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   TIGRFAMs; TIGR00801; ncs2; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..432
FT                   /note="Uracil permease"
FT                   /id="PRO_0000165956"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   432 AA;  45182 MW;  C015DB9AD515F4F4 CRC64;
     MNKPVLDIQD RPTVGQWITL SLQHLFAMFG ATILVPYLVG LDPSIALLTS GLGTLAFLLI
     TKWQVPAYLG SSFAYIAPII AAKTAGGPGA AMIGSFLAGL VYGVVALIIK KAGYRWVMKL
     LPPVVVGPVI IVIGLGLAGT AVGMAMNGPD GKYSLLHFSV ALVTLAATIV CSVLARGMLS
     LIPVLVGIVV GYLYALAVGL VDLSKVAAAK WFEWPDFLIP FADYPVRVTW EIVMLMVPVA
     IVTLSEHIGH QLVLSKVVGR DLIQKPGLHR SILGDGTATM ISALLGGPPK TTYGENIGVL
     AITRVYSVYV LAGAAVIAIA FGFVGKITAL ISSIPTPVMG GVSILLFGII ASSGLRMLID
     SRVDFGQTRN LVIASVILVI GIGGAVLKIS DSFQITGMAL SAIVGVLLNL ILPGRPQAAE
     NLFEENQSDH VA