ID   PYRRH_PYRAP             Reviewed;          20 AA.
AC   P37362; P80307;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Pyrrhocoricin;
OS   Pyrrhocoris apterus (Sap sucking bug) (Cimex apterus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Pentatomomorpha; Pyrrhocoroidea; Pyrrhocoridae; Pyrrhocoris.
OX   NCBI_TaxID=37000;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Hemolymph;
RX   PubMed=8002963; DOI=10.1042/bj3000567;
RA   Cociancich S., Dupont A., Hegy G., Lanot R., Holder F., Hetru C.,
RA   Hoffmann J.A., Bulet P.;
RT   "Novel inducible antibacterial peptides from a hemipteran insect, the sap-
RT   sucking bug Pyrrhocoris apterus.";
RL   Biochem. J. 300:567-575(1994).
RN   [2]
RP   GLYCOSYLATION AT THR-11.
RX   PubMed=10076062; DOI=10.1016/s0304-4165(98)00169-x;
RA   Hoffmann R., Bulet P., Urge L., Otvoes L. Jr.;
RT   "Range of activity and metabolic stability of synthetic antibacterial
RT   glycopeptides from insects.";
RL   Biochim. Biophys. Acta 1426:459-467(1999).
CC   -!- FUNCTION: Antibacterial peptide. Affects Gram-negative bacteria E.coli
CC       1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria
CC       M.luteus and B.subtilis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: O-linked glycan consists of a Gal-GalNAc disaccharide, O-
CC       glycosylation is essential for full biological activity.
CC       {ECO:0000269|PubMed:10076062}.
CC   -!- SIMILARITY: Belongs to the drosocin family. {ECO:0000305}.
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DR   PIR; S44465; S44465.
DR   PDB; 3DPO; X-ray; 2.10 A; C/D=7-11.
DR   PDB; 3DPP; X-ray; 2.50 A; C/D=7-20.
DR   PDB; 3DPQ; X-ray; 2.60 A; C/D/G/H=7-20.
DR   PDB; 4EZN; X-ray; 1.80 A; C/D=1-20.
DR   PDB; 4EZQ; X-ray; 2.00 A; B=12-20.
DR   PDB; 4HY9; X-ray; 1.55 A; C/D=1-11.
DR   PDB; 4HYB; X-ray; 1.70 A; C/D=1-10.
DR   PDB; 4J2O; X-ray; 2.65 A; A/B/C/D/E/F=2-16.
DR   PDB; 5FDV; X-ray; 2.80 A; 1y/2y=1-16.
DR   PDB; 5HD1; X-ray; 2.70 A; 1z/2z=1-20.
DR   PDBsum; 3DPO; -.
DR   PDBsum; 3DPP; -.
DR   PDBsum; 3DPQ; -.
DR   PDBsum; 4EZN; -.
DR   PDBsum; 4EZQ; -.
DR   PDBsum; 4HY9; -.
DR   PDBsum; 4HYB; -.
DR   PDBsum; 4J2O; -.
DR   PDBsum; 5FDV; -.
DR   PDBsum; 5HD1; -.
DR   AlphaFoldDB; P37362; -.
DR   SMR; P37362; -.
DR   iPTMnet; P37362; -.
DR   EvolutionaryTrace; P37362; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Direct protein sequencing;
KW   Glycoprotein; Immunity; Innate immunity; Secreted.
FT   PEPTIDE         1..20
FT                   /note="Pyrrhocoricin"
FT                   /id="PRO_0000043590"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        11
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:10076062"
FT   STRAND          4..9
FT                   /evidence="ECO:0007829|PDB:4J2O"
SQ   SEQUENCE   20 AA;  2341 MW;  F4320EC2FF29462C CRC64;
     VDKGSYLPRP TPPRPIYNRN