ID   PYRR_HAEIN              Reviewed;         179 AA.
AC   P44722;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Bifunctional protein PyrR;
DE   Includes:
DE     RecName: Full=Pyrimidine operon regulatory protein;
DE   Includes:
DE     RecName: Full=Uracil phosphoribosyltransferase;
DE              Short=UPRTase;
DE              EC=2.4.2.9;
GN   Name=pyrR; OrderedLocusNames=HI_0459;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Regulates the transcription of the pyrimidine nucleotide
CC       (pyr) operon in response to exogenous pyrimidines. {ECO:0000250}.
CC   -!- FUNCTION: Also displays a weak uracil phosphoribosyltransferase
CC       activity which is not physiologically significant. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         uracil; Xref=Rhea:RHEA:13017, ChEBI:CHEBI:17568, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57865, ChEBI:CHEBI:58017; EC=2.4.2.9;
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. PyrR subfamily. {ECO:0000305}.
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DR   EMBL; L42023; AAC22117.1; -; Genomic_DNA.
DR   PIR; G64069; G64069.
DR   RefSeq; NP_438620.1; NC_000907.1.
DR   RefSeq; WP_005649361.1; NC_000907.1.
DR   AlphaFoldDB; P44722; -.
DR   SMR; P44722; -.
DR   STRING; 71421.HI_0459; -.
DR   EnsemblBacteria; AAC22117; AAC22117; HI_0459.
DR   KEGG; hin:HI_0459; -.
DR   PATRIC; fig|71421.8.peg.479; -.
DR   eggNOG; COG2065; Bacteria.
DR   HOGENOM; CLU_094234_2_1_6; -.
DR   OMA; PIQPDFC; -.
DR   PhylomeDB; P44722; -.
DR   BioCyc; HINF71421:G1GJ1-475-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0004845; F:uracil phosphoribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_01219; PyrR; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR023050; PyrR.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Reference proteome; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN           1..179
FT                   /note="Bifunctional protein PyrR"
FT                   /id="PRO_0000183038"
FT   MOTIF           100..112
FT                   /note="PRPP-binding"
FT                   /evidence="ECO:0000250"
FT   BINDING         39..40
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         104..112
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         137
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         161
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   179 AA;  20528 MW;  1E96972790C0A9E9 CRC64;
     MEKIIIDHDR FLRTISRISH EIIEKHQTLD DLVIVGIKRR GAEIAELLQR RVEELSSINL
     PSMELDITFY RDDLTLVDQE DKMPVYSGSS QYLNIQDKTV ILVDDVLFTG RTIRAAMDAL
     TDFGRAAKIE LVIFVDRGHR ELPIRADYVG KNVPTSRDEL VQVRTEKQDG CYEVAILGK