ID   PYRX_HELPJ              Reviewed;         378 AA.
AC   Q9ZMG9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Probable dihydroorotase-like protein;
DE   AltName: Full=Aspartate carbamoyltransferase 42 kDa non-catalytic chain;
GN   Name=pyrC'; OrderedLocusNames=jhp_0251;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Non-functional DHOase. {ECO:0000250|UniProtKB:Q59712}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       DHOase family. PyrC' subfamily. {ECO:0000305}.
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DR   EMBL; AE001439; AAD05827.1; -; Genomic_DNA.
DR   PIR; E71956; E71956.
DR   RefSeq; WP_000924871.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZMG9; -.
DR   SMR; Q9ZMG9; -.
DR   STRING; 85963.jhp_0251; -.
DR   EnsemblBacteria; AAD05827; AAD05827; jhp_0251.
DR   KEGG; hpj:jhp_0251; -.
DR   PATRIC; fig|85963.30.peg.763; -.
DR   eggNOG; COG0044; Bacteria.
DR   OMA; SHYAKSY; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.40.10; -; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Pyrimidine biosynthesis.
FT   CHAIN           1..378
FT                   /note="Probable dihydroorotase-like protein"
FT                   /id="PRO_0000147288"
SQ   SEQUENCE   378 AA;  42244 MW;  03AFC4A06B07A00B CRC64;
     MLLKNASFYD DEVLKRADIR LKDSLIIEIE ENLSPTNNEE VVECEDLFVL PSFIDLSVTN
     LEGYENLKQK AFKGGVGLLN VFNGDQSGIK NIMAIKNNQL ADIATLKNKG GEILIAPSDA
     FLELISHYAK SYNLPLLISL ENSFEALNSG ALAYELGQNF VDNAFENTRL VRFMEVSRAL
     QIPVLLDKVN SIATLKLIKA FNDLGAKLQA QTPLSHLILD ESVYEDYEPR FKIAPPLRDK
     EGQNALKEAL KNNEIAMLTS LHASKNSNAQ LFEESAFGCE SIEDAFSVAY TFLVQKKVIS
     FQQLIKVMTI NQAKFLKLNA GEVKENQLAN LMIVDLNAQT RVSNQNSPFY GLELYGEVQR
     MILKGQTTFI KENACKKS