ID   PYRX_HELPY              Reviewed;         378 AA.
AC   O25045;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Probable dihydroorotase-like protein;
DE   AltName: Full=Aspartate carbamoyltransferase 42 kDa non-catalytic chain;
GN   Name=pyrC'; OrderedLocusNames=HP_0266;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Non-functional DHOase. {ECO:0000250|UniProtKB:Q59712}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       DHOase family. PyrC' subfamily. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07332.1; -; Genomic_DNA.
DR   PIR; B64553; B64553.
DR   RefSeq; NP_207064.1; NC_000915.1.
DR   RefSeq; WP_000924910.1; NC_018939.1.
DR   AlphaFoldDB; O25045; -.
DR   SMR; O25045; -.
DR   IntAct; O25045; 1.
DR   STRING; 85962.C694_01345; -.
DR   PaxDb; O25045; -.
DR   DNASU; 899074; -.
DR   EnsemblBacteria; AAD07332; AAD07332; HP_0266.
DR   KEGG; hpy:HP_0266; -.
DR   PATRIC; fig|85962.47.peg.286; -.
DR   eggNOG; COG0044; Bacteria.
DR   OMA; SHYAKSY; -.
DR   PhylomeDB; O25045; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Pyrimidine biosynthesis; Reference proteome.
FT   CHAIN           1..378
FT                   /note="Probable dihydroorotase-like protein"
FT                   /id="PRO_0000147287"
SQ   SEQUENCE   378 AA;  42362 MW;  E4691ECC0E0659F0 CRC64;
     MLLKNASFYD DEVLKRADIR LKDSLITEIK ENLSPINNEE VIECRDLFVL PSFIDLSVTG
     LEGYENLKQK AFKGGVGLLN VFNCDQSGIK NIMAIKNNQL ADIATLKNKG GEILIAPSDA
     FLELISHYAK SYNLPLLISL ENSFEALNSG ELAYELGQNF VENAFENTRL VRFMEVSRAL
     QIPVLLDKVN SITTLKLIKA FNDLGAKLQA QTPLSHLVLD ESVYEDYEPR FKIAPPLRDK
     ESQNALKEAL KNNEIAMLTS LHASKNSNAQ LFEESAFGCE SIEDAFSVAY TFLVQKKVIS
     FQQLIKVMAI NQAKFLKLNA GEVKENQLAN LMIVDLNAQT RVSNQNSPFY GLELYGEVQR
     MILKGQTTFI KENACKKS