ID   PYRX_PSEAE              Reviewed;         423 AA.
AC   Q51551;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   08-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Dihydroorotase-like protein;
DE   AltName: Full=Aspartate carbamoyltransferase 44 kDa non-catalytic chain;
GN   Name=pyrC'; Synonyms=pyrX; OrderedLocusNames=PA0401;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RA   Vickrey J.F., Schurr M.J., Benjamin R.C., Cunin R., Shanley M.S.,
RA   O'Donovan G.A.;
RT   "Nucleotide sequence of the gene coding for dihydroorotase-like polypeptide
RT   from Pseudomonas aeruginosa.";
RL   Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Non-functional DHOase. {ECO:0000250|UniProtKB:Q59712}.
CC   -!- SUBUNIT: Heterododecamer of 6 active PyrB subunits and 6 non-catalytic
CC       PyrC' subunits. {ECO:0000250|UniProtKB:Q59712}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       DHOase family. PyrC' subfamily. {ECO:0000305}.
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DR   EMBL; L19649; AAA25977.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG03790.1; -; Genomic_DNA.
DR   PIR; G83595; G83595.
DR   RefSeq; NP_249092.1; NC_002516.2.
DR   RefSeq; WP_003114891.1; NZ_QZGE01000016.1.
DR   AlphaFoldDB; Q51551; -.
DR   SMR; Q51551; -.
DR   STRING; 287.DR97_3369; -.
DR   PaxDb; Q51551; -.
DR   PRIDE; Q51551; -.
DR   EnsemblBacteria; AAG03790; AAG03790; PA0401.
DR   GeneID; 878275; -.
DR   KEGG; pae:PA0401; -.
DR   PATRIC; fig|208964.12.peg.422; -.
DR   PseudoCAP; PA0401; -.
DR   HOGENOM; CLU_015572_1_0_6; -.
DR   InParanoid; Q51551; -.
DR   OMA; QHAQEPR; -.
DR   PhylomeDB; Q51551; -.
DR   BioCyc; PAER208964:G1FZ6-405-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0004151; F:dihydroorotase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd01317; DHOase_IIa; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR004722; DHOase.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Pyrimidine biosynthesis; Reference proteome.
FT   CHAIN           1..423
FT                   /note="Dihydroorotase-like protein"
FT                   /id="PRO_0000147284"
FT   CONFLICT        55
FT                   /note="P -> A (in Ref. 1; AAA25977)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        296
FT                   /note="K -> N (in Ref. 1; AAA25977)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        312
FT                   /note="A -> P (in Ref. 1; AAA25977)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   423 AA;  44150 MW;  AD950F9EE4556F21 CRC64;
     MTISIRGARV IDPASDLDQV GDLHIEAGKI VAIGAAPAGF SAQKTLDGAG LVAAPGLVDL
     SVALREPGYG RKGNVESETR AAAAGGTTSL CCPPYTRPVL DTPAVAELIL DRAREAGNAK
     VYPIGALTRG FGGEQLSELV ALRDTGCVAF TNGLHGFASN RILRRALEYA ATFDLTVIFT
     SQDTDLAEGG LAHEGPTASF LGLAGIPETA ETVALARNLL LVEQSGVRAH FSQLTSARGI
     ELVAQAQARG LPVTCDVALY QLILTDEALV GFSSLYHVQP PLRTRADREA LREAVKNGVV
     QAIASHHQPH EADAKNAPFA ATEPGISGAE LLLPLAMTLV QDGLLDLPTL LARLSHGPAQ
     ALRLPAGRLA VGQAADLVLF DPQGSTLAGE SWYSKGQNSP FVGHCLPGRV RYTLVDGHLT
     HEG