ID   PYTF_ASPTN              Reviewed;         296 AA.
AC   Q0CZG9;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=MFS-type transporter pytF {ECO:0000303|PubMed:32077283};
DE   AltName: Full=Pyranterreones biosynthesis cluster protein F {ECO:0000303|PubMed:32077283};
GN   Name=pytF {ECO:0000303|PubMed:32077283}; ORFNames=ATEG_00915;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INDUCTION, FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=32077283; DOI=10.1021/acs.jnatprod.9b01140;
RA   Tang S., Zhang W., Li Z., Li H., Geng C., Huang X., Lu X.;
RT   "Discovery and characterization of a PKS-NRPS hybrid in Aspergillus terreus
RT   by genome mining.";
RL   J. Nat. Prod. 83:473-480(2020).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of pyranterreones, a family of antioxidative compounds
CC       (PubMed:32077283). Directly involved in the secretion of pyranterreones
CC       (PubMed:32077283). {ECO:0000269|PubMed:32077283}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:32077283};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is positively regulated by the cluster-specific
CC       transcription factor pytR. {ECO:0000269|PubMed:32077283}.
CC   -!- DISRUPTION PHENOTYPE: Blocks the secretions of pyranterreones.
CC       {ECO:0000269|PubMed:32077283}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR   EMBL; CH476594; EAU39561.1; -; Genomic_DNA.
DR   RefSeq; XP_001211001.1; XM_001211001.1.
DR   AlphaFoldDB; Q0CZG9; -.
DR   SMR; Q0CZG9; -.
DR   EnsemblFungi; EAU39561; EAU39561; ATEG_00915.
DR   GeneID; 4355678; -.
DR   VEuPathDB; FungiDB:ATEG_00915; -.
DR   eggNOG; KOG2504; Eukaryota.
DR   HOGENOM; CLU_001265_1_3_1; -.
DR   OMA; YREINGT; -.
DR   OrthoDB; 916876at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..296
FT                   /note="MFS-type transporter pytF"
FT                   /id="PRO_0000450471"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        265
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   296 AA;  32460 MW;  15210DA70968924A CRC64;
     MTTKEAIADM ALEAQEEDDA GPPDGGFRAW LVVLGGFLAY FVTFGMLNSF GTFQEYYGEK
     LLPGRSTSEI SWIGSLQLFL LFIGGLFFGP VFDAKGSKVL FIPGTLLLSL SQMMVSLCKE
     YYQFILAQSL LFGIAVAMLF YPTISAISHW FHHRRGLAMG IVLTGSSLGG IAWPLILERL
     FAVVGFPWGL RIVGFISFAL LAPACFMVIP RLPPRKSGGL SKADLSEGLK DRRYWLTVVG
     MLFVIWGMFI PFYYIPLFAM DHGVNSSFAN SLISILNAGS FVGRIVSGAL ADKLGR