ID   PYTR_ASPTN              Reviewed;         858 AA.
AC   Q0CZG5;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Transcription factor pytR {ECO:0000303|PubMed:32077283};
DE   AltName: Full=Pyranterreones biosynthesis cluster protein R {ECO:0000303|PubMed:32077283};
GN   Name=pytR {ECO:0000303|PubMed:32077283}; ORFNames=ATEG_00919;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=32077283; DOI=10.1021/acs.jnatprod.9b01140;
RA   Tang S., Zhang W., Li Z., Li H., Geng C., Huang X., Lu X.;
RT   "Discovery and characterization of a PKS-NRPS hybrid in Aspergillus terreus
RT   by genome mining.";
RL   J. Nat. Prod. 83:473-480(2020).
CC   -!- FUNCTION: Transcription factor that regulates th eexpression of the
CC       gene cluster that mediates the biosynthesis of Pyranterreones, a family
CC       of antioxidative compounds. {ECO:0000269|PubMed:32077283}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- DISRUPTION PHENOTYPE: Loses the ability to produce pyranterreones.
CC       {ECO:0000269|PubMed:32077283}.
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DR   EMBL; CH476594; EAU39565.1; -; Genomic_DNA.
DR   RefSeq; XP_001211005.1; XM_001211005.1.
DR   AlphaFoldDB; Q0CZG5; -.
DR   SMR; Q0CZG5; -.
DR   EnsemblFungi; EAU39565; EAU39565; ATEG_00919.
DR   GeneID; 4355682; -.
DR   VEuPathDB; FungiDB:ATEG_00919; -.
DR   eggNOG; ENOG502QVBS; Eukaryota.
DR   HOGENOM; CLU_333151_0_0_1; -.
DR   OrthoDB; 536411at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..858
FT                   /note="Transcription factor pytR"
FT                   /id="PRO_0000450474"
FT   DNA_BIND        39..65
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          72..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   858 AA;  94774 MW;  56C90B66B190FA14 CRC64;
     MAHFSRVASD PSLAPQPSAP SGLDSSTTSS SSTGLHRSCT FCRARKIRCS SGPICSACRE
     RNINCIYSPE ARKGRPRRRG TNTSNAQAKK GDQENPTLGR ELDRMFQEYF ISKTGSRSNL
     FQNSIASFHR HIRKPTPAHT PAPTPRPKLS YDSLLSFLAH EMVEVLLLRF GAFGDEQLQS
     NPHQYFYITS LADETTPSMF DPPRRQKSPL AALGKHRVVQ MVHFWFFMHP LSAVVSKTLL
     LSAIQDETVD TALLAIILAD AFESFDPKDN PNTTGSVRPE ESPQELLQFA ASQLQHRPCS
     NVDAGPISTA QALILLGWRE MSQGNARRAT CYIGYTCRVV AREHQRRSRD EGDRERMKLN
     GTDIGEVEQE ILRNIYWLCL STTTWAFMQI DQPFTLLVPD EIPDFPSLDE TTSAVLCLDR
     ASNNISTLPS QVQAMRWLWP LSHVTSTVAH IYTLYLNAPT EESKVHAAPW HTRHIYQLHR
     LLRSRFHPSN LSLEIHGILI QAIQLVEREV TIPSTKSFLL TSYYTIIVHI LFSPERRAPT
     PITPAIIQAL GECISAILTI AARVPSLPTS QVPAQSSYAT RTLAVSLDSC SHALVRLHSQ
     YDWQLKEHRD AAPALTKLAD YADQAHQVCR SDFLGNYASV LRPAKKRLKW VKSALRALCM
     SPSSQPVSMS EVTDAANAAF PSLSPKKTPF SLDRPGDLSL GSSACSIHDF IPQSPGFPPS
     QLVPPLEIPD PGFFSDNASF ESLLGFPGMA RSDIYSRTSN SPSSHLTMGT LDGQAFGNLF
     LMSPDISAPD VDSMLQSNPF DTSNPVSNSG AERVCGTGAG LLGRSTGAQY DSHLHMDASK
     PFPAWNPGIA EEYGKYGE