PYVG_ASPV1
ID PYVG_ASPV1 Reviewed; 543 AA.
AC A0A2V5GRP3; A0A7M4B4V7;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 1.
DT 25-MAY-2022, entry version 14.
DE RecName: Full=MFS-type transporter pyvG {ECO:0000303|PubMed:33117309};
DE AltName: Full=Pyranoviolin A biosynthesis cluster protein G {ECO:0000303|PubMed:33117309};
GN Name=pyvG {ECO:0000303|PubMed:33117309}; ORFNames=BO99DRAFT_485677;
OS Aspergillus violaceofuscus (strain CBS 115571).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1450538;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RX PubMed=33117309; DOI=10.3389/fmicb.2020.562063;
RA Wei X., Chen L., Tang J.W., Matsuda Y.;
RT "Discovery of pyranoviolin A and its biosynthetic gene cluster in
RT Aspergillus violaceofuscus.";
RL Front. Microbiol. 11:562063-562063(2020).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115571;
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC the biosynthesis of pyranoviolin A, a pyranonigrin analog with a C-3
CC methoxy group (PubMed:33117309). May be involved in the secretion of
CC pyranoviolin A (Probable). {ECO:0000269|PubMed:33117309,
CC ECO:0000305|PubMed:33117309}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC {ECO:0000305}.
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DR EMBL; BR001648; FAA01297.1; -; Genomic_DNA.
DR EMBL; KZ825234; PYI13688.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2V5GRP3; -.
DR Proteomes; UP000249829; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..543
FT /note="MFS-type transporter pyvG"
FT /id="PRO_0000452821"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 24..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 543 AA; 59572 MW; A552A8D256B3C59B CRC64;
MAHLLTNSPI GLLGRWLSGG RLLPPTEQQP GFQLPPPYRL AATRTQPQQQ QEQEQEQEQA
KPATRPPWNE PQITAEGAIQ VGWYSSTDPD NPQNWSFGAK LLVYLEVNLI TFMVYMSVAI
FSAAEGEFRT VFGVSRSVTE LGMSLYVLGY GTGPMIWSPL SEIPSVGRNP PYVVSVTIFL
LLSIPTAVVN NVPGFLILRF LQGFFGSPGL ATGGASIADV TGLTHLPYGL YVWAVCSIAG
PAVAPVIAGF SVPVKGWHWS MWEVLWAAGG CFVFLLFLPE TSGPAILHLR AQRLRALTGN
PAFQSQSEIA VRDARPTQIV YDALVIPWKI NALDPAILFT TVYIGLVYAI FYSYFEVLPR
VYITMHAMTL GQLGLIFLGA IVGTLLVLPG YFAFTHWSLN ADFRRGVWPR PEKRLVPALC
GSVLVPVGLF LFAWTARPDL HWVVPTVGLV LEVAGMSLVI QCVFSYVAVA YLRYSASLFA
INDLARAYLA FAAIMWSDPL YDRLGVARGT TLLAGLTVGC VGGMFTLYWW GPALRKRSRF
ASD
