PYY2_BOVIN
ID PYY2_BOVIN Reviewed; 80 AA.
AC P06833;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Caltrin;
DE AltName: Full=Calcium transport inhibitor;
DE AltName: Full=Peptide YY-2;
DE Short=Peptide YY2;
DE AltName: Full=Seminalplasmin;
DE Short=SPLN;
DE Flags: Precursor;
GN Name=PYY2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2206400; DOI=10.1089/dna.1990.9.437;
RA Wagner S., Freudenstein J., Scheit K.H.;
RT "Characterization by cDNA cloning of the mRNA for seminalplasmin, the major
RT basic protein of bull semen.";
RL DNA Cell Biol. 9:437-442(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Seminal vesicle;
RX PubMed=8485159; DOI=10.1016/0167-4781(93)90248-c;
RA Kleine Kuhlmann J., Scheit K.K.;
RT "Characterization of the gene for seminalplasmin, a secretory protein of
RT the bovine seminal vesicle.";
RL Biochim. Biophys. Acta 1173:85-86(1993).
RN [3]
RP PROTEIN SEQUENCE OF 33-79.
RX PubMed=3863108; DOI=10.1073/pnas.82.19.6490;
RA Lewis R.V., San Agustin J., Kruggel W., Lardy H.A.;
RT "The structure of caltrin, the calcium-transport inhibitor of bovine
RT seminal plasma.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:6490-6491(1985).
RN [4]
RP PROTEIN SEQUENCE OF 33-79.
RX PubMed=16453469; DOI=10.1002/j.1460-2075.1983.tb01561.x;
RA Theil R., Scheit K.H.;
RT "Amino acid sequence of seminalplasmin, an antimicrobial protein from bull
RT semen.";
RL EMBO J. 2:1159-1163(1983).
RN [5]
RP PROTEIN SEQUENCE OF 33-77.
RX PubMed=2423370; DOI=10.1016/0014-5793(86)80615-9;
RA Sitaram N., Kumari V.K., Bhargava P.M.;
RT "Seminalplasmin and caltrin are the same protein.";
RL FEBS Lett. 201:233-236(1986).
RN [6]
RP FUNCTION.
RX PubMed=2334517;
RA Krauhs E., Preuss K.D., Scheit K.H.;
RT "Functional properties of peptides derived from seminalplasmin: binding to
RT monospecific anti-seminalplasmin immunoglobulins G and calmodulin.";
RL Biol. Chem. Hoppe-Seyler 371:111-115(1990).
RN [7]
RP REVIEW.
RX PubMed=7786287; DOI=10.1002/bies.950170509;
RA Sitaram N., Nagaraj R.;
RT "Seminal plasmin.";
RL Bioessays 17:415-422(1995).
CC -!- FUNCTION: Inhibits calcium transport into spermatozoa; it does not bind
CC directly to calcium. Binds to calmodulin. Inhibits the growth of
CC microorganisms. Seem to act as an antibiotic by permeabilizing the
CC bacterial membrane. {ECO:0000269|PubMed:2334517}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-11 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=Ref.3; Type=Miscellaneous discrepancy; Note=Transposition of two peptides and an extra Lys.; Evidence={ECO:0000305};
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DR EMBL; M36982; AAA30759.1; -; mRNA.
DR EMBL; X62310; CAA44190.1; -; Genomic_DNA.
DR PIR; A35572; A35572.
DR RefSeq; NP_776381.1; NM_173956.2.
DR AlphaFoldDB; P06833; -.
DR STRING; 9913.ENSBTAP00000054402; -.
DR TCDB; 8.A.106.1.1; the caltrin/peptide yy (caltrin) family.
DR PaxDb; P06833; -.
DR Ensembl; ENSBTAT00000065967; ENSBTAP00000054402; ENSBTAG00000045652.
DR GeneID; 280905; -.
DR KEGG; bta:280905; -.
DR CTD; 23615; -.
DR VEuPathDB; HostDB:ENSBTAG00000045652; -.
DR GeneTree; ENSGT00740000117120; -.
DR HOGENOM; CLU_2573321_0_0_1; -.
DR OMA; SWPAMAI; -.
DR OrthoDB; 1629306at2759; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000045652; Expressed in mammary gland fat and 56 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0031841; F:neuropeptide Y receptor binding; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR PANTHER; PTHR10533; PTHR10533; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Calcium; Calmodulin-binding;
KW Direct protein sequencing; Reference proteome; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000305|PubMed:16453469,
FT ECO:0000305|PubMed:2423370, ECO:0000305|PubMed:3863108"
FT CHAIN 33..80
FT /note="Caltrin"
FT /id="PRO_0000025403"
SQ SEQUENCE 80 AA; 8977 MW; BEB7627C55FDA246 CRC64;
MMAGRRSWPA MATVLLALLV CLGELVDSKP QPSDEKASPD KHHRFSLSRY AKLANRLANP
KLLETFLSKW IGDRGNRSVK
