ID   PYYA_DANRE              Reviewed;          97 AA.
AC   Q9I8P2; B3DGK4;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Peptide YY-A;
DE   AltName: Full=Peptide YY;
DE   AltName: Full=Peptide YYa;
DE   Flags: Precursor;
GN   Name=pyya; Synonyms=pyy;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=10936170; DOI=10.1046/j.1471-4159.2000.0750908.x;
RA   Soederberg C., Wraith A., Ringvall M., Yan Y.-L., Postlethwait J.H.,
RA   Brodin L., Larhammar D.;
RT   "Zebrafish genes for neuropeptide Y and peptide YY reveal origin by
RT   chromosome duplication from an ancestral gene linked to the homeobox
RT   cluster.";
RL   J. Neurochem. 75:908-918(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in brainstem neurons, and in the
CC       telencephalon. Also expressed in intestinal endocrine cells.
CC       {ECO:0000269|PubMed:10936170}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   EMBL; AF233875; AAF79942.1; -; Genomic_DNA.
DR   EMBL; BC162428; AAI62428.1; -; mRNA.
DR   EMBL; BC162436; AAI62436.1; -; mRNA.
DR   RefSeq; NP_001157843.1; NM_001164371.1.
DR   RefSeq; NP_571091.1; NM_131016.2.
DR   AlphaFoldDB; Q9I8P2; -.
DR   STRING; 7955.ENSDARP00000108040; -.
DR   TCDB; 8.A.106.2.1; the caltrin/peptide yy (caltrin) family.
DR   PaxDb; Q9I8P2; -.
DR   Ensembl; ENSDART00000128786; ENSDARP00000108040; ENSDARG00000053449.
DR   Ensembl; ENSDART00000186352; ENSDARP00000152843; ENSDARG00000053449.
DR   GeneID; 30211; -.
DR   KEGG; dre:30211; -.
DR   CTD; 30211; -.
DR   ZFIN; ZDB-GENE-980526-71; pyya.
DR   eggNOG; ENOG502S267; Eukaryota.
DR   GeneTree; ENSGT00940000160643; -.
DR   HOGENOM; CLU_162379_1_0_1; -.
DR   InParanoid; Q9I8P2; -.
DR   OMA; DSNRDQR; -.
DR   OrthoDB; 1542445at2759; -.
DR   PhylomeDB; Q9I8P2; -.
DR   TreeFam; TF332778; -.
DR   Reactome; R-DRE-375276; Peptide ligand-binding receptors.
DR   Reactome; R-DRE-418594; G alpha (i) signalling events.
DR   PRO; PR:Q9I8P2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000053449; Expressed in brain and 12 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031841; F:neuropeptide Y receptor binding; IDA:ZFIN.
DR   GO; GO:0031843; F:type 2 neuropeptide Y receptor binding; IDA:ZFIN.
DR   GO; GO:0007631; P:feeding behavior; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         29..64
FT                   /note="Peptide YY-A"
FT                   /id="PRO_0000025395"
FT   PROPEP          68..97
FT                   /note="C-terminal extension"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000025396"
FT   MOD_RES         64
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   97 AA;  11175 MW;  96EA07EF0991AC2D CRC64;
     MAVMLKPWTV VATVLICVLL CLGTFVDAYP PKPENPGDDA APEELAKYYT ALRHYINLIT
     RQRYGKRSTS EDVMAELLFG DDTEHKQRSR YDDSFMW